Details of Drug

Drug General Information (ID: D1138)
Drug Name	Nimodipine
Drug Type	Small molecule
Drug Synonymous	Admon; Brainal; Calnit; Kenesil; Modus; NimoGel; NimodipinISIS; Nimodipino; Nimodipinum; Nimotop; Periplum; Remontal; Almirall Brand of Nimodipine; Alpharma Brand of Nimodipine; Andromaco Brand of Nimodipine; Bayer Brand of Nimodipine; Bayvit Brand of Nimodipine; Cantabria Brand of Nimodipine; Elan Brand of Nimodipine; Esteve Brand of Nimodipine; Hexal Brand of Nimodipine; Nimodipin Hexal; Nimodipin ISIS; Nimodipino Bayvit; Vita Brand of Nimodipine; Bay-E 9736; DRG-0139; EG-1961; N-149; NIMOTOP (TN); Nimodipin-ISIS; Nimodipino [INN-Spanish]; Nimodipinum [INN-Latin]; Nimotop (TN); Nimotop(TM); Nimotop, Nimodipine; Bay-e-9736; Nimodipine (USAN/INN); Nimodipine [USAN:BAN:INN]; Periplum, Nimotop, BRN 0459792, DRG-0139; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3′-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;1-methylethyl 2-(methyloxy)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 2-Methoxyethyl-1-methylethyl ester; 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-methoxyethyl 1-methylethyl ester; 3,5-pyridinecarboxylic acid 2-methoxyethyl 1-methylethyl ester; 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl), 2-methoxyethyl 1-methylethyl ester; 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide Click to Show/Hide
Disease Class	BA85: Coronary vasospastic disease
Therapeutic Class	Vasodilator Agents
Structure
Structure	3D Structure		2D Structure
Formula	C21H26N2O7
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChIKey	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
External Link
	Pubchem ID	4497
	CAS Number	66085-59-4
	CHEBI ID	7575
	TTD ID	D0XN1F
	INTEDE ID	DR1161
	VARIDT ID	DR01211

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM021 Interference with first-pass metabolism BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM072 Increased risk of nephrotoxicity BM081 Increased risk of ventricular arrhythmias BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Nimodipine
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[3], [4], [64]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[15], [17], [22]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[4], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
	CYP450 enzyme inhibition					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[76], [77]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[78]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[100], [101], [102]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[103], [104]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[116]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[140]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[141]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[142]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[143], [144]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[149]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[152]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[4], [160]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[164], [3], [4], [165], [1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[100], [101], [102]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[103], [104]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[168]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[172]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[4], [173]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[187]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[192]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [4], [193]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[195]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[197]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[3], [4], [206], [207]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[209]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[221], [222], [223], [224], [225], [226], [227], [228], [229]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[234]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[4], [235]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[236]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[241]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[246]
D1721		Zileuton	C11H12N2O2S	60490	Minor		Inter Info	[252]
	Interference with first-pass metabolism					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Minor		Inter Info	[253]
	CYP450 enzyme induction					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[2], [1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[2], [1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[2], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[2], [1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [7], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[2], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[2], [1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[2], [1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[8], [9], [10]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [7], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[8], [9], [10]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[2], [1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[4], [56], [57]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[58], [59], [60]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[58], [59], [60]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3], [4], [84], [85]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[58], [59], [60]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[3], [105], [106], [107], [108], [109]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[122]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[3], [150]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[151]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[153]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[154], [2], [155], [156], [157], [158]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[159]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[188]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[196]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[154], [2], [155], [156], [157], [158]
D1024		Methohexital	C14H18N2O3	9034	Moderate		Inter Info	[58], [59], [60]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[58], [59], [60]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[3], [105], [106], [107], [108], [109]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[213], [214], [215]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[4], [220]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[58], [59], [60]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [4], [239]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3], [4], [240], [239]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[242]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[4], [243]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[58], [59], [60]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [4], [239]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[147], [148]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[3], [166], [167]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[3], [166], [167]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[237], [238]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[237], [238]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 138
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[26], [27], [28]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[26], [27], [28]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[26], [27], [28]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[26], [27], [28]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[26], [27], [28]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[26], [27], [28]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[73], [74], [75]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[26], [27], [28]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[26], [27], [28]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[26], [27], [28]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[26], [27], [28]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[26], [27], [28]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[26], [27], [28]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[26], [27], [28]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[26], [27], [28]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[86], [87], [88]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[26], [27], [28]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[89], [90], [91]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[26], [27], [28]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[113], [114], [115]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[26], [27], [28]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[118], [119], [120]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[118], [119], [120]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[26], [27], [28]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[26], [27], [28]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[26], [27], [28]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[26], [27], [28]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[3], [4], [121]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[26], [27], [28]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[26], [27], [28]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[26], [27], [28]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[26], [27], [28]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[26], [27], [28]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[26], [27], [28]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[26], [27], [28]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[26], [27], [28]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[3], [4], [121]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[73], [74], [75]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[26], [27], [28]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[3], [145], [146]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[26], [27], [28]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[26], [27], [28]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[26], [27], [28]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[26], [27], [28]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[26], [27], [28]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[26], [27], [28]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[26], [27], [28]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[26], [27], [28]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[26], [27], [28]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[26], [27], [28]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[26], [27], [28]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[3], [4], [121]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[26], [27], [28]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[90], [161]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[26], [27], [28]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[26], [27], [28]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[3], [4], [169]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[26], [27], [28]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[73], [74], [75]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[26], [27], [28]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[26], [27], [28]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[4], [170], [171]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[26], [27], [28]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [90], [184], [185]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[73], [74], [75]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[26], [27], [28]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[26], [27], [28]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [90], [184], [185]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[201], [202], [164], [4], [165], [203], [204]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[26], [27], [28]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[205]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[26], [27], [28]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[26], [27], [28]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[26], [27], [28]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[26], [27], [28]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[73], [74], [75]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[26], [27], [28]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[26], [27], [28]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[26], [27], [28]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[208]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[210], [211], [212]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[26], [27], [28]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[26], [27], [28]
D1183		Opium	NA	NA	Moderate		Inter Info	[26], [27], [28]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[26], [27], [28]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[26], [27], [28]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[26], [27], [28]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[26], [27], [28]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[26], [27], [28]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[219]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [90], [184], [185]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [90], [184], [185]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[26], [27], [28]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [90], [184], [185]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[230]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [90], [184], [185]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[4], [170], [171]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[73], [74], [75]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[26], [27], [28]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[26], [27], [28]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[26], [27], [28]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[26], [27], [28]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[113], [114], [115]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[26], [27], [28]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[26], [27], [28]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[26], [27], [28]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[26], [27], [28]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[4], [170], [171]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[92], [93], [94], [95], [86], [96], [87], [97], [88], [98], [99]
D0711		Garlic	NA	NA	Minor		Inter Info	[247], [248]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[249], [250]
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[110], [111], [112]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[110], [111], [112]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[110], [111], [112]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[110], [111], [112]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[110], [111], [112]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[110], [111], [112]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[110], [111], [112]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[110], [111], [112]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[110], [111], [112]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[110], [111], [112]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[110], [111], [112]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[110], [111], [112]
	Increased risk of atrioventricular block					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[6]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[4], [82], [83]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[189]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[4], [251]
	Increased risk of bradycardia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[3], [4], [5]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[3], [11]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[117]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[4], [139], [83]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[162], [163]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[3], [186]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[190], [191]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[194]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[216]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[164], [3], [4], [217], [218]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[231], [232], [233]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[190], [191]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[231], [232], [233]
	Increased risk of cardiac depression					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[32], [41], [49]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[32], [41], [49]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[32], [41], [49]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[32], [41], [49]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[32], [41], [49]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[32], [41], [49]
	Increased risk of nephrotoxicity					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[3], [4]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[3], [4]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[3], [4]
D0276		Cefazolin	C14H14N8O4S3	33255	Moderate		Inter Info	[3], [4]
D0279		Cefepime	C19H24N6O5S2	5479537	Moderate		Inter Info	[3], [4]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[3], [4]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[3], [4]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[3], [4]
D0286		Cefotetan	C17H17N7O8S4	53025	Moderate		Inter Info	[3], [4]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[3], [4]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[3], [4]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[3], [4]
D0290		Cefradine	C16H19N3O4S	38103	Moderate		Inter Info	[3], [4]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[3], [4]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[3], [4]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[3], [4]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[3], [4]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[3], [4]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[3], [4]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[3], [4]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[3], [4]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[3], [4]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[3], [4]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[3], [4]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[3], [4]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[3], [4], [245]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[61], [62], [63]
D0240		Calcium glucoheptonate	C14H26CaO16	62859	Moderate		Inter Info	[61], [62], [63]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[79], [80], [81]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[79], [80], [81]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[79], [80], [81]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[61], [62], [63]
D0237		Calcium chloride	CaCl2H4O2	24844	Moderate		Inter Info	[61], [62], [63]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[61], [62], [63]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[61], [62], [63]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Moderate		Inter Info	[61], [62], [63]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[61], [62], [63]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[61], [62], [63]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[79], [80], [81]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[79], [80], [81]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Moderate		Inter Info	[61], [62], [63]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[79], [80], [81]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[79], [80], [81]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[79], [80], [81]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[79], [80], [81]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[79], [80], [81]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[79], [80], [81]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[198], [199], [200]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[79], [80], [81]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[79], [80], [81]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[79], [80], [81]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[79], [80], [81]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[79], [80], [81]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[79], [80], [81]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[79], [80], [81]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[79], [80], [81]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[79], [80], [81]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[79], [80], [81]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[79], [80], [81]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[79], [80], [81]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1905		Tetrofosmin	C18H40O4P2	4274	Moderate		Inter Info	[244]

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122	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
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140	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
141	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
142	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
143	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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152	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
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160	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
161	Product Information. Corlopam (fenoldopam). Neurex, Menlo Park, CA.
162	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
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166	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
167	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
168	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
169	Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
170	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
171	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
172	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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181	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
182	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
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187	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
188	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
189	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
190	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
191	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
192	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
193	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
194	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
195	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
196	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
197	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
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207	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
208	Product Information. Natrecore (nesiritide) Scios Inc, Sunnyvale, CA.
209	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
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213	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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216	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
217	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
218	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
219	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
220	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
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225	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
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231	Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
232	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
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235	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
236	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
237	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
238	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
239	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
240	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
241	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
242	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
243	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
244	Product Information. Myoview (tetrofosmin). GE Healthcare, Princeton, NJ.
245	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
246	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
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249	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
250	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
251	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
252	Product Information. Zylo Filmtab (zileuton). Abbott Pharmaceutical, Abbott Park, IL.
253	Tartara A, Galimberti CA, Manni R, et al "Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients." Br J Clin Pharmacol 32 (1991): 335-40. [PMID: 1777370]

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