Drug General Information (ID: DDI5T3ZIM0)
Drug Name			Valproic acid		Drug Info		Nimodipine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Vasodilator Agents
Structure

Mechanism of Valproic acid-Nimodipine Interaction (Severity Level: Minor)
Interference with first-pass metabolism Click to Show/Hide Mechanism Graph
Drug Name		Valproic acid				Nimodipine
Mechanism		Interference with first pass metabolism				Extensive first-pass metabolism
Key Mechanism Factor 1
		Factor Name		First-pass metabolism
		Factor Description		First-pass metabolism is a drug metabolism phenomenon in which the concentration of a drug, especially when administered orally, is greatly reduced before it reaches the systemic circulation. Interfering with the first-pass metabolism of a drug may affect the total amount of drug reaching the systemic circulation.
Mechanism Description		Decreased metabolism of Nimodipine caused by Valproic acid mediated interference with first-pass metabolism

References
1	Tartara A, Galimberti CA, Manni R, et al "Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients." Br J Clin Pharmacol 32 (1991): 335-40. [PMID: 1777370]