Details of Drug

Drug General Information (ID: D1061)
Drug Name	Midodrine
Drug Type	Small molecule
Drug Synonymous	Alphamine; Amatine; Gutron; Hipertan; Metligene; Midamine; Midodrin; Midodrina; Midodrinum; ProAmatine; MIDODRINE HYDROCHLORIDE; Midodrine HCL; Midodrine Monohydrochloride; Midodrine hydrochloride [USAN]; A 4020 Linz; St 1085; TS 701; A-4020 Linz; Midodrina [INN-Spanish]; Midodrine (INN); Midodrine [BAN:INN]; Midodrine [INN:BAN]; Midodrine hydrochloride [USAN:JAN]; Midodrinum [INN-Latin]; Pro-Amatine; Proamatine (TN); ST-1085; St. Peter 224; Midodrine hydrochloride (JAN/USAN); Pro-Amatine (TN); DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid; N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide; N-{2-[2,5-bis(methyloxy)phenyl]-2-hydroxyethyl}glycinamide; [+/-]-1-[2,5-Dimethoxyphenyl]-2-glycinamidoethanol; Acetamide, 2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)-, hydrochloride; Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, monohydrochloride; (+-)-1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride; (+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide monohydrochloride; (+-)-Midodrine hydrochloride; (+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol; (-)-Midodrin hydrochloride; (-)-Midodrine hydrochloride; (RS)-N'-(beta-Hydroxy-2,5-dimethoxy-phenethyl)glycinamid; 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol; 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride; 1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamid; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethylacetamide; 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride; 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hyyroxyethyl)acetamide monohydrochloride; 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide; 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide hydrochloride Click to Show/Hide
Disease Class	BA21: Orthostatic hypotension
Therapeutic Class	Vasoconstrictor Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H18N2O4
InChI	1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
InChIKey	PTKSEFOSCHHMPD-UHFFFAOYSA-N
Canonical SMILES	COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
External Link
	Pubchem ID	4195
	CAS Number	42794-76-3
	CHEBI ID	6933
	TTD ID	D02XJY
	INTEDE ID	DR1088
	VARIDT ID	DR01164

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM024 Competitive inhibition of metabolic enzyme BM028 Competitive inhibition of renal tubular secretion BM041 Additive hypertensive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM083 Potentiated the pharmacological effects (Unspecific) BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Midodrine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[7]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[11]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[16]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[17], [18]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[19]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[20]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[21]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[31]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[10], [34]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[35]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[10], [36]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[51]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[52]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[53]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[54]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[57]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[58]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[61]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[56]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[33]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[55]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[10], [64], [65]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[5]
D0664		Flecainide	C17H20F6N2O3	3356	Minor		Inter Info	[5]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[66], [67], [68]
D1015		Metformin	C4H11N5	4091	Minor		Inter Info	[5]
D1343		Procainamide	C13H21N3O	4913	Minor		Inter Info	[5]
D1371		Quinidine	C20H24N2O2	441074	Minor		Inter Info	[5]
D1381		Ranitidine	C13H22N4O3S	3001055	Minor		Inter Info	[5]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Minor		Inter Info	[5]
D1631		Triamterene	C12H11N7	5546	Minor		Inter Info	[5]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 75
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3], [4]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[1], [4], [5]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [2], [3], [6], [4], [5]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[1], [4], [5]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[1], [4], [5]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[10], [5]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[13], [14], [15]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[10], [5]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[25], [26], [27], [28], [29], [30]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[10], [5]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[10], [5]
D0505		Dipivefrin (ophthalmic)	C19H29NO5	3105	Moderate		Inter Info	[10], [5]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[10], [5]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[10], [5]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[32]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[25], [26], [27], [28], [29], [30]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[10], [5]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[10], [5]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[10], [5]
D0582		Epinephrine (ophthalmic)	C9H13NO3	5816	Moderate		Inter Info	[10], [5]
D0583		Epinephrine (topical)	C9H13NO3	5816	Moderate		Inter Info	[10], [5]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[13], [14], [15]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[13], [14], [15]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[10], [5]
D0913		Levmetamfetamine (nasal)	C10H15N	36604	Moderate		Inter Info	[10], [5]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[25], [26], [27], [28], [29], [30]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[10], [5]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[13], [14], [15]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[10], [5]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[10], [5]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[10], [5]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[10], [5]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[10], [5]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[10], [5]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[10], [5]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[25], [26], [27], [28], [29], [30]
D1107		Naphazoline (nasal)	C14H14N2	4436	Moderate		Inter Info	[10], [5]
D1108		Naphazoline (ophthalmic)	C14H14N2	4436	Moderate		Inter Info	[10], [5]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[10], [5]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[13], [14], [15]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[13], [14], [15]
D1204		Oxymetazoline (nasal)	C16H24N2O	4636	Moderate		Inter Info	[10], [5]
D1205		Oxymetazoline (ophthalmic)	C16H24N2O	4636	Moderate		Inter Info	[10], [5]
D1206		Oxymetazoline (topical)	C16H24N2O	4636	Moderate		Inter Info	[10], [5]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[10], [5]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[10], [5]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[10], [5]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[10], [5]
D1280		Phenylephrine (topical)	C9H13NO2	6041	Moderate		Inter Info	[10], [5]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[10], [5]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[13], [14], [15]
D1358		Propylhexedrine (nasal)	C10H21N	7558	Moderate		Inter Info	[10], [5]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[10], [5]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[13], [14], [15]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[13], [14], [15]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[13], [14], [15]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[13], [14], [15]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[59]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[60]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[25], [26], [27], [28], [29], [30]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[13], [14], [15]
D1567		Tetryzoline (nasal)	C13H16N2	5419	Moderate		Inter Info	[10], [5]
D1568		Tetryzoline (ophthalmic)	C13H16N2	5419	Moderate		Inter Info	[10], [5]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[25], [26], [27], [28], [29], [30]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[13], [14], [15]
D1712		Xylometazoline (nasal)	C16H24N2	5709	Moderate		Inter Info	[10], [5]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[10], [62], [63]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[10], [5]
	Increased risk of atrioventricular block					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[5]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[5]
	Increased risk of bradycardia					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[5]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[5]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[5]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[5]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[5]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[5]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[5]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[5]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[5]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[5]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[5]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[5]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[5]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[5]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[5]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[5]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[5]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[5]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[5]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[5]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[5]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[5]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[5]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[5]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[5]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[5]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[5]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[5]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[5]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[5]
	Increased risk of hyperpyrexia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[8], [9]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[22], [23], [24]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[22], [23], [24]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[22], [23], [24]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[22], [23], [24]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[10], [5], [12]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[10], [5], [12]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[10], [5], [12]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[10], [5], [12]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[10], [5], [12]

References
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5	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
6	Product Information. Bellergal-S (ergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
7	Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
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15	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
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