Details of Drug-Drug Interaction
| Drug General Information (ID: DDIXHT0138) | |||||||||
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| Drug Name | Midodrine | Drug Info | Alfuzosin | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Vasoconstrictor Agents | Antihypertensive Agents | |||||||
| Structure | |||||||||
| Mechanism of Midodrine-Alfuzosin Interaction (Severity Level: Moderate) | |||||||||
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| Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Midodrine | Alfuzosin | |||||||
| Mechanism |
Hypertensive effects Alpha-1 adrenergic receptor Agonist |
Hypotensive effects Alpha-1 adrenergic receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Adrenergic receptor alpha-1 | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Alpha adrenergic blockers should be avoided, if possible, in patients taking midodrine for orthostatic hypotension. | ||||||||