Drug General Information (ID: DDIC1WVGHU)
Drug Name			Midodrine		Drug Info		Procainamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Antiarrhythmic Agents
Structure

Mechanism of Midodrine-Procainamide Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Midodrine				Procainamide
Mechanism		Midodrine				Competitive inhibition of renal tubular secretion of midodrine
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Midodrine caused by Procainamide mediated competitive inhibition of renal tubular secretion

References
1	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.