Details of Drug

Details of Drug

 Drug General Information (ID: D0850)
  Drug Name
Iron sucrose
  Drug Type Small molecule
  Drug Synonymous
Iron sugar; Saccharated iron; Saccharated iron oxide; Sucroferric oxyhydroxide; Saccharated ferric oxide; FERRIC HYDROXIDE SUCROSE COMPLEX; Ferrivenin; Venoferrum; Encifer; Feojectin; Ferijet; Hippiron; Proferrin; Sucrofer; Velphoro; Iviron; Fesin; Ferum Hausmann; Ferrum Vitis; Neo-ferrum; Ferosoft S; Fe-back; Ferplex SS; Fe-lib; Colliron I.V.; Sucrose, iron complex; Ferrum Hausmann i.v.; Iron oxide, saccharated; Succharated ferric oxide; Ferric oxide, saccharated; UNII-FZ7NYF5N8L; FZ7NYF5N8L; IRON SUCROSE COMPLEX; IRON OXIDE SACCHARATED; Iron sucrose [USAN:USP:BAN]; EINECS 232-464-7; NSC 27278; XI 921; XI-921; Succharated ferric oxide [USAN:JAN]; DB09146; Ferric saccharate ...iron oxide (mix.); IRON(III) HYDROXIDE SUCROSE COMPLEX; Q27888379
    Click to Show/Hide
  Therapeutic Class Iron Supplement
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H29Fe5Na2O23
  InChI InChI=1S/C12H22O11.5Fe.2Na.4H2O.8O/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12;;;;;;;;;;;;;;;;;;;/h4-11,13-20H,1-3H2;;;;;;;;4*1H2;;;;;;;;/q;5*+3;2*+1;;;;;8*-2/p-1/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;/m1.................../s1
  InChIKey FWZTTZUKDVJDCM-CEJAUHOTSA-M
  Canonical SMILES C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CO)O)O)CO)O)O)O)O.O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3]
  External Link
Pubchem ID 91663255

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM007  Pharmacodynamic antagonistic effects
BM003  Complex formation
BM004  Adsorption
BM009  Altered absorption (Unspecific)
BM013  Competitive binding of plasma proteins
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Iron sucrose
      Affected gastrointestinal absorption
   Complex formation Drug Num:  12
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0034
 
Alendronic acid
 
C4H13NO7P2
 
2088 
Moderate    Inter Info   
[5], [6], [7]
D0441
 
Demeclocycline
 
C21H21ClN2O8
 
54680690 
Moderate    Inter Info   
[12], [13], [8]
D0530
 
Doxycycline
 
C22H24N2O8
 
54671203 
Moderate    Inter Info   
[12], [13], [8]
D0623
 
Etidronic acid
 
C2H8O7P2
 
3305 
Moderate    Inter Info   
[5], [6], [7]
D0783
 
Ibandronate
 
C9H23NO7P2
 
60852 
Moderate    Inter Info   
[5], [6], [7]
D1175
 
Omadacycline
 
C29H40N4O7
 
54697325 
Moderate    Inter Info   
[12], [13], [8]
D1445
 
Sarecycline
 
C24H29N3O8
 
54681908 
Moderate    Inter Info   
[12], [13], [8]
D1070
 
Minocycline
 
C23H27N3O7
 
54675783 
Moderate    Inter Info   
[12], [13], [8]
D1209
 
Oxytetracycline
 
C22H24N2O9
 
54675779 
Moderate    Inter Info   
[12], [13], [8]
D1412
 
Risedronic acid
 
C7H11NO7P2
 
5245 
Moderate    Inter Info   
[5], [6], [7]
D1564
 
Tetracycline
 
C22H24N2O8
 
54675776 
Moderate    Inter Info   
[12], [13], [8]
D1584
 
Tiludronic acid
 
C7H9ClO6P2S
 
60937 
Moderate    Inter Info   
[5], [6], [7]
   Adsorption Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0233
 
Calcifediol
 
C27H44O2
 
5283731 
Moderate    Inter Info   
[8]
D0328
 
Cholecalciferol
 
C27H44O
 
5280795 
Moderate    Inter Info   
[8]
D0495
 
Dihydrotachysterol
 
C28H46O
 
5311071 
Moderate    Inter Info   
[8]
D0527
 
Doxercalciferol
 
C28H44O2
 
5281107 
Moderate    Inter Info   
[8]
D0591
 
Ergocalciferol
 
C28H44O
 
5280793 
Moderate    Inter Info   
[8]
D0925
 
Levothyroxine
 
C15H11I4NO4
 
5819 
Moderate    Inter Info   
[20], [8], [21]
D0934
 
Liothyronine
 
C15H12I3NO4
 
5920 
Moderate    Inter Info   
[20], [8], [21]
D0935
 
Liotrix
 
C30H21I7N2Na2O8
 
71371 
Moderate    Inter Info   
[20], [8], [21]
D1226
 
Paricalcitol
 
C27H44O3
 
5281104 
Moderate    Inter Info   
[8]
D1577
 
Thyroid, porcine
 
NA
 
NA
Moderate    Inter Info   
[20], [8], [21]
   Altered absorption (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0847
 
Iron
 
Fe
 
23925 
Moderate    Inter Info   
[14], [15], [16]
D0649
 
Ferrous fumarate
 
C4H2FeO4
 
6433164 
Moderate    Inter Info   
[17], [14], [18], [15], [16]
D0650
 
Ferrous gluconate
 
C12H22FeO14
 
23616740 
Moderate    Inter Info   
[17], [14], [18], [15], [16]
D0651
 
Ferrous sulfate anhydrous
 
FeO4S
 
24393 
Moderate    Inter Info   
[14], [15], [16]
D0849
 
Iron protein succinylate
 
NA
 
NA
Moderate    Inter Info   
[17], [14], [18], [15], [16]
      Affected organization distribution
   Competitive binding of plasma proteins Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0708
 
Gallium chloride Ga-67
 
Cl3Ga
 
73415785 
Moderate    Inter Info   
[19]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1776
 
Dimercaprol
 
C3H8OS2
 
3080 
Major    Inter Info   
[1], [2], [3]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Major    Inter Info   
[4]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[9], [10], [11]
D1703
 
Vitamin E
 
C29H50O2
 
14985 
Moderate    Inter Info   
[22], [23]
References
1 Desmedt S, Spinewine A, Jadoul M, Henrard S, Wouters D, Dalleur O. Impact of a clinical decision support system for drug dosage in patients with renal failure.?Int J Clin Pharm. 2018;40(5):1225-1233. [PMID: 29785684]
2 Chenoweth MB "Clinical uses of metal-binding drugs." Clin Pharmacol Ther 9 (1968): 365-87. [PMID: 4984845]
3 Product Information. BAL in Oil (dimercaprol). Becton Dickinson, Franklin Lakes, NJ.
4 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
5 Product Information. Actonel (risedronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
6 Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
7 Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
8 Product Information. Velphoro (sucroferric oxyhydroxide). Fresenius Medical Care North America, Lexington, MA.
9 Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
10 Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
11 Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
12 Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54. [PMID: 946598]
13 Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
14 Product Information. Feraheme (ferumoxytol). Alza Pharmaceuticals, Mountain View, CA.
15 Product Information. INFeD (iron dextran). Schein Pharmaceuticals Inc, Florham Park, NJ.
16 Product Information. Venofer (iron sucrose) American Regent Laboratories Inc, Shirley, NY.
17 Product Information. Accrufer (ferric maltol). Shield Therapeutics, Wilmington, DE.
18 Product Information. Ferrlecit (sodium ferric gluconate complex). sanofi-aventis, Bridgewater, NJ.
19 Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.
20 Campbell NR, Hasinoff BB, Stalts H, Rao B, Wong NC "Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism." Ann Intern Med 117 (1992): 1010-3. [PMID: 1443969]
21 Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
22 Graeber JE, Williams ML, Oski FA "The use of intramuscular vitamin E in the premature infant. Optimum dose and iron interaction." J Pediatr 90 (1977): 282-4
23 Melhorn DK, Gross S "Relationships between iron-dextran and vitamin E in iron deficiency anemia in children." J Lab Clin Med 74 (1969): 789-802