Drug General Information (ID: DDINJ1DW9C)
Drug Name			Demeclocycline		Drug Info		Iron sucrose		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Iron Supplement
Structure

Mechanism of Demeclocycline-Iron sucrose Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Demeclocycline				Iron sucrose
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Iron sucrose due to formation of complexes caused by Demeclocycline

Recommended Action
Management		Doxycycline should be administered at least 1 hour before sucroferric oxyhydroxide. Omadacycline administration with sucroferric oxyhydroxide should be separated by 4 hours. No dosing recommendations are available for use with other tetracyclines, although patients should consider following the same precaution.

References
1	Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54. [PMID: 946598]
2	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
3	Product Information. Velphoro (sucroferric oxyhydroxide). Fresenius Medical Care North America, Lexington, MA.