Drug General Information (ID: DDIBC8VF7R)
Drug Name			Levothyroxine		Drug Info		Iron sucrose		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antithyroid Agents				Iron Supplement
Structure

Mechanism of Levothyroxine-Iron sucrose Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Levothyroxine				Iron sucrose
Mechanism		Adsorbed by sucroferric oxyhydroxide				Sucroferric oxyhydroxide
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Levothyroxine due to adsorption of Iron sucrose

Recommended Action
Management		Oral formulations of levothyroxine should not be prescribed with sucroferric oxyhydroxide.

References
1	Campbell NR, Hasinoff BB, Stalts H, Rao B, Wong NC "Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism." Ann Intern Med 117 (1992): 1010-3. [PMID: 1443969]
2	Product Information. Velphoro (sucroferric oxyhydroxide). Fresenius Medical Care North America, Lexington, MA.
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]