Details of Drug

Drug General Information (ID: D0805)
Drug Name	Inotersen
Drug Type	Small molecule
Drug Synonymous	UNII-0IEO0F56LV; 0IEO0F56LV; Inotersen [USAN]; ISIS 420915 Click to Show/Hide
Disease Class	5D00: Amyloidosis
Therapeutic Class	Metabolic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C230H318N69O121P19S19
InChI	1S/C230H318N69O121P19S19/c1-98-53-280(219(312)262-178(98)231)140-43-110(121(382-140)66-364-425(328,444)406-114-47-144(292-90-254-150-183(236)244-85-249-188(150)292)387-126(114)71-368-423(326,442)404-112-45-142(282-59-104(7)197(303)274-225(282)318)383-122(112)67-363-421(324,440)403-111-44-141(281-58-103(6)196(302)273-224(281)317)385-124(111)69-366-427(330,446)410-119-52-149(297-95-260-156-194(297)268-217(242)271-204(156)310)391-130(119)75-372-431(334,450)419-167-139(401-215(177(167)362-42-32-352-22)299-97-261-157-195(299)269-218(243)272-205(157)311)84-381-438(341,457)418-165-136(398-213(175(165)360-40-30-350-20)291-64-109(12)202(308)279-230(291)323)82-379-437(340,456)417-163-135(397-211(173(163)358-38-28-348-18)289-62-107(10)200(306)277-228(289)321)81-378-435(338,454)414-161-132(394-209(171(161)356-36-26-346-16)286-56-101(4)181(234)265-222(286)315)78-375-433(336,452)412-159-120(65-300)392-207(169(159)354-34-24-344-14)288-61-106(9)199(305)276-227(288)320)402-422(325,441)367-70-125-115(48-145(386-125)293-91-255-151-184(237)245-86-250-189(151)293)407-426(329,445)365-68-123-113(46-143(384-123)283-60-105(8)198(304)275-226(283)319)405-424(327,443)371-74-129-118(51-148(390-129)296-94-259-155-193(296)267-216(241)270-203(155)309)409-429(332,448)370-72-127-116(49-146(388-127)294-92-256-152-185(238)246-87-251-190(152)294)408-428(331,447)369-73-128-117(50-147(389-128)295-93-257-153-186(239)247-88-252-191(153)295)411-430(333,449)374-77-138-166(176(361-41-31-351-21)214(400-138)298-96-258-154-187(240)248-89-253-192(154)298)420-439(342,458)380-83-137-164(174(359-39-29-349-19)212(399-137)290-63-108(11)201(307)278-229(290)322)416-436(339,455)377-80-134-162(172(357-37-27-347-17)210(396-134)287-57-102(5)182(235)266-223(287)316)415-434(337,453)376-79-133-160(170(355-35-25-345-15)208(395-133)285-55-100(3)180(233)264-221(285)314)413-432(335,451)373-76-131-158(301)168(353-33-23-343-13)206(393-131)284-54-99(2)179(232)263-220(284)313/h53-64,85-97,110-149,158-177,206-215,300-301H,23-52,65-84H2,1-22H3,(H,324,440)(H,325,441)(H,326,442)(H,327,443)(H,328,444)(H,329,445)(H,330,446)(H,331,447)(H,332,448)(H,333,449)(H,334,450)(H,335,451)(H,336,452)(H,337,453)(H,338,454)(H,339,455)(H,340,456)(H,341,457)(H,342,458)(H2,231,262,312)(H2,232,263,313)(H2,233,264,314)(H2,234,265,315)(H2,235,266,316)(H2,236,244,249)(H2,237,245,250)(H2,238,246,251)(H2,239,247,252)(H2,240,248,253)(H,273,302,317)(H,274,303,318)(H,275,304,319)(H,276,305,320)(H,277,306,321)(H,278,307,322)(H,279,308,323)(H3,241,267,270,309)(H3,242,268,271,310)(H3,243,269,272,311)/t110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174+,175+,176+,177+,206+,207+,208+,209+,210+,211+,212+,213+,214+,215+,421?,422?,423?,424?,425?,426?,427?,428?,429?,430?,431?,432?,433?,434?,435?,436?,437?,438?,439?/m0/s1
InChIKey	KLEGMTRDCCDFJK-XDQSQZFTSA-N
Canonical SMILES	CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=S)(O)OC3CC(OC3COP(=S)(O)OC4CC(OC4COP(=S)(O)OC5C(OC(C5OCCOC)N6C=NC7=C6N=C(NC7=O)N)COP(=S)(O)OC8C(OC(C8OCCOC)N9C=C(C(=O)NC9=O)C)COP(=S)(O)OC1C(OC(C1OCCOC)N1C=C(C(=O)NC1=O)C)COP(=O)(OC1C(OC(C1OCCOC)N1C=C(C(=NC1=O)N)C)COP(=S)(O)OC1C(OC(C1OCCOC)N1C=C(C(=O)NC1=O)C)CO)S)N1C=NC2=C1N=C(NC2=O)N)N1C=C(C(=O)NC1=O)C)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(CC(O1)N1C=C(C(=NC1=O)N)C)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(CC(O1)N1C=C(C(=O)NC1=O)C)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C1N=C(NC2=O)N)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(C(C(O1)N1C=NC2=C(N=CN=C21)N)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=O)NC1=O)C)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=NC1=O)N)C)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=NC1=O)N)C)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=NC1=O)N)C)OCCOC)O
External Link
	Pubchem ID	121492004
	CAS Number	1492984-65-2
	TTD ID	D0R3BV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM027 Decreased renal excretion due to nephrotoxicity BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM072 Increased risk of nephrotoxicity
Relation Graph

Full list of drugs interacting with Inotersen
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[70]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[71]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[82]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[83]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[85]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 93
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1], [2], [3]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1], [2], [3]
D0047		Alteplase	NA	NA	Major		Inter Info	[1], [2], [3]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1], [2], [3]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[1], [2], [3]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1], [2], [3]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2], [3]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2], [3]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2], [3]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1], [2], [3]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2], [3]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2], [3]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1], [2], [3]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2], [3]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2], [3]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1], [2], [3]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1], [2], [3]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1], [2], [3]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2], [3]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[12]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2], [3]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2], [3]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1], [2], [3]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2], [3]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2], [3]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1], [2], [3]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1], [2], [3]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1], [2], [3]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [2], [3]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1], [2], [3]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2], [3]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[2], [21]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [3]
D1251		Pentoxifylline	C13H18N4O3	4740	Major		Inter Info	[1], [2], [3]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1], [2], [3]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1], [2], [3]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[1], [2], [3]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1], [2], [3]
D1395		Reteplase	NA	NA	Major		Inter Info	[1], [2], [3]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2], [3]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2], [3]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1], [2], [3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1], [2], [3]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1], [2], [3]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1], [2], [3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1], [2], [3]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1], [2], [3]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1], [2], [3]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[1], [2], [3]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[1], [2], [3]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1], [2], [3]
D1669		Urokinase	NA	NA	Major		Inter Info	[1], [2], [3]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[1], [2], [3]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[24], [25], [26]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[2], [67]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[24], [25], [26]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[24], [25], [26]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[24], [25], [26]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[72]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[24], [25], [26]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[24], [25], [26]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[2], [84]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[24], [25], [26]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
	Increased risk of hepatotoxicity					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[16], [17], [18]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[19]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[20]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[22]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[23]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1], [27]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[68], [69]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[73]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[32], [1], [74], [75], [76]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[77], [78], [79], [80]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[77], [78], [79], [80]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[81]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[77], [78], [79], [80]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[86], [87]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [88]
	Increased risk of nephrotoxicity					Drug Num: 91
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0022		Acyclovir	C8H11N5O3	135398513	Major		Inter Info	[1], [3]
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1], [3]
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1], [3]
D0075		Amphotericin B	C47H73NO17	5280965	Major		Inter Info	[1], [3]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Major		Inter Info	[1], [3]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Major		Inter Info	[1], [3]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Major		Inter Info	[1], [3]
D0142		Bacitracin	C66H103N17O16S	10909430	Major		Inter Info	[1], [3]
D0145		Balsalazide	C17H15N3O6	54585	Major		Inter Info	[1], [3]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1], [3]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[1], [3]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1], [3]
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[4]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1], [3]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1], [3]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Major		Inter Info	[1], [3]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[1], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [3]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1], [3]
D0434		Deferoxamine	C25H48N6O8	2973	Major		Inter Info	[1], [3]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [3]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Major		Inter Info	[1], [3]
D0550		Edetate disodium anhydrous	C10H14N2Na2O8	8759	Major		Inter Info	[1], [3]
D0623		Etidronic acid	C2H8O7P2	3305	Major		Inter Info	[1], [3]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [3]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[1], [3]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [3]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [3]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [3]
D0709		Gallium nitrate	GaN3O9	61635	Major		Inter Info	[1], [3]
D0710		Ganciclovir	C9H13N5O4	135398740	Major		Inter Info	[1], [3]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [3]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[13], [14], [15]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[13], [14], [15]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[13], [14], [15]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[13], [14], [15]
D0783		Ibandronate	C9H23NO7P2	60852	Major		Inter Info	[1], [3]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [3]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[1], [3]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [3]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1], [3]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1], [3]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[7], [8], [9]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[7], [8], [9]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[7], [8], [9]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[7], [8], [9]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [3]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [3]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [3]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1], [3]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1], [3]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [3]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [3]
D1009		Mesalazine	C7H7NO3	4075	Major		Inter Info	[1], [3]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1], [3]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[1], [3]
D1091		Moxetumomab Pasudotox	NA	NA	Major		Inter Info	[1], [3]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [3]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [3]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [3]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [3]
D1173		Olsalazine	C14H10N2O6	22419	Major		Inter Info	[1], [3]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [3]
D1217		Pamidronic acid	C3H11NO7P2	4674	Major		Inter Info	[1], [3]
D1245		Penicillamine	C5H11NO2S	5852	Major		Inter Info	[1], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [3]
D1310		Polymyxin B	C56H98N16O13	49800004	Major		Inter Info	[1], [3]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[1], [3]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[1], [3]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[1], [3]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [3]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[1], [3]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[1], [3]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [3]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [3]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [3]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[1], [3]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [3]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [3]
D1672		Valaciclovir	C13H20N6O4	135398742	Major		Inter Info	[1], [3]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[1], [3]
D1676		Valganciclovir	C14H22N6O5	135413535	Major		Inter Info	[1], [3]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Major		Inter Info	[1], [3]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Major		Inter Info	[1], [3]

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