Details of Drug

Drug General Information (ID: D0770)
Drug Name	Hydralazine
Drug Type	Small molecule
Drug Synonymous	Apresolin; Apresoline; Apressin; Apressoline; Aprezolin; HLZ; Hidral; Hidralazin; Hidralazina; Hipoftalin; Hydralazin; Hydralazinum; Hydrallazin; Hydrallazine; Hydrazinophthalazine; Hypophthalin; Idralazina; Hidralazina [Spanish]; Idralazina [DCIT]; Idralazina [Italian]; BA 5968; C 5968; Ciba 5968; Praparat 5968; Apresoline (TN); Apressin (pharmaceutical); C-5068; C-5968; Hidral (TN); Hidralazina [INN-Spanish]; Hydralazine (INN); Hydralazine [INN:BAN]; Hydralazinum [INN-Latin]; Hydrazone 1(2H)-phthalazinone; Phthalazin-1-ylhydrazine; [2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride; (1Z)-1(2H)-Phthalazinone hydrazone; (2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone, hydrazone; 1-Hydrazinophthalazine; 1-Phthalazinylhydrazine; 6-Hydralazine Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C8H8N4
InChI	1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
InChIKey	RPTUSVTUFVMDQK-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C=NN=C2NN
External Link
	Pubchem ID	3637
	CAS Number	86-54-4
	CHEBI ID	5775
	TTD ID	D0K1XK
	VARIDT ID	DR00942

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM018 Non-CYP450 enzyme inhibition BM021 Interference with first-pass metabolism BM042 Additive hypotensive effects BM074 Increased risk of peripheral neuropathy BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Hydralazine
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0043		Alosetron	C17H18N4O	2099	Minor		Inter Info	[79]
	Interference with first-pass metabolism					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1244		Penbutolol	C18H29NO2	37464	Minor		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 126
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[5]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[6], [7], [8]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[9], [10], [11]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[6], [7], [8]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[12], [13], [14]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[6], [7], [8]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[6], [7], [8]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[12], [15], [16]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[17], [18], [19]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[6], [7], [8]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[17], [18], [19]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[17], [18], [19]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[6], [7], [8]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[6], [7], [8]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[6], [7], [8]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[6], [7], [8]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[6], [7], [8]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[6], [7], [8]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[6], [7], [8]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[6], [7], [8]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[6], [7], [8]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[6], [7], [8]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[6], [7], [8]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[6], [7], [8]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[33], [3], [34]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[6], [7], [8]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[6], [7], [8]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[35], [36], [37]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[6], [7], [8]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[6], [7], [8]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[6], [7], [8]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[6], [7], [8]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[28], [39], [40]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[13], [41]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[6], [7], [8]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[6], [7], [8]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[33], [28], [42]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[43], [44], [45]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[6], [7], [8]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[33], [28], [48]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[33], [28], [48]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[6], [7], [8]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[6], [7], [8]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[33], [28], [48]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[6], [7], [8]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[28], [52], [53]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[54]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[6], [7], [8]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[55]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[56], [57], [58]
D1183		Opium	NA	NA	Moderate		Inter Info	[6], [7], [8]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [13], [69], [70]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[6], [7], [8]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [13], [69], [70]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[71]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[28], [39], [40]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[6], [7], [8]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[6], [7], [8]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[6], [7], [8]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[6], [7], [8]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[6], [7], [8]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[28], [39], [40]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[6], [7], [8]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [13], [69], [70]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[12], [15], [72]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [13], [69], [70]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[6], [7], [8]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[6], [7], [8]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[6], [7], [8]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[6], [7], [8]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[6], [7], [8]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[6], [7], [8]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[6], [7], [8]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[6], [7], [8]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[6], [7], [8]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[6], [7], [8]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[73], [74], [53]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[6], [7], [8]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[6], [7], [8]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[6], [7], [8]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[75]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [13], [69], [70]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[6], [7], [8]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[6], [7], [8]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [13], [69], [70]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[43], [44], [45]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[6], [7], [8]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[6], [7], [8]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[28], [39], [40]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[6], [7], [8]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[43], [44], [45]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[6], [7], [8]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[20], [21], [22], [23], [9], [24], [10], [25], [11], [26], [27]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[6], [7], [8]
D0711		Garlic	NA	NA	Minor		Inter Info	[105], [106]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[107], [108]
	Increased risk of peripheral neuropathy					Drug Num: 76
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[2], [3], [4]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[2], [3], [4]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[2], [3], [4]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[30], [31], [32]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[2], [3], [4]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[2], [3], [4]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[2], [3], [4]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[2], [3], [4]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[2], [3], [4]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[2], [3], [4]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[2], [3], [4]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[2], [3], [4]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[2], [3], [4]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[2], [3], [4]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[2], [3], [4]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[2], [3], [4]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[2], [3], [4]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[2], [3], [4]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[2], [46], [47]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[2], [3], [4]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[2], [3], [4]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[2], [3], [4]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[2], [3], [4]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[2], [3], [4]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[2], [3], [4]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[2], [3], [4]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[2], [3], [4]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[2], [3], [4]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[2], [3], [4]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[2], [3], [4]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[2], [3], [4]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[2], [3], [4]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[2], [3], [4]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[2], [3], [4]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[2], [3], [4]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[2], [3], [4]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[2], [3], [4]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[2], [3], [4]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [3], [4]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[2], [3], [4]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[2], [3], [4]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[2], [3], [4]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[2], [3], [4]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[2], [3], [4]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[2], [3], [4]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[2], [3], [4]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[2], [3], [4]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[2], [3], [4]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[2], [3], [4]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[2], [3], [4]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[2], [3], [4]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[2], [3], [4]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[2], [3], [4]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[2], [3], [4]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[2], [3], [4]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[2], [3], [4]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[2], [3], [4]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[30], [33], [28], [76]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[2], [3], [4]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[2], [3], [4]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[2], [3], [4]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[2], [3], [4]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[2], [3], [4]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[2], [3], [4]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[30], [78]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[28], [29]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[28], [29]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[28], [29]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[38]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[38]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[38]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[28], [29]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[38]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[38]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[28], [29]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[28], [29]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[49], [50], [51]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[38]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[38]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[28], [29]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[28], [29]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[38]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[38]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[38]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[38]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[38]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[38]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[38]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[28], [29]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[38]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[38]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[38]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[38]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[28], [29]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[28], [29]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[38]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[38]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[28], [29]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[77], [13]

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