Details of Drug

Drug General Information (ID: D0748)
Drug Name	Halazepam
Drug Type	Small molecule
Drug Synonymous	Halazepamum; Pacinone; Paxipam; Sch 12041; Schering 12041; Alapryl (TN); Halazepamum [INN-Latin]; Pacinone (TN); Paxipam (TN); Sch-12041; Halazepam (USAN/INN); Halazepam [USAN:BAN:INN]; 7-Chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one; 7=Chlor-5-phenyl-1-(2,2,2-trifluorethyl)-1H-1,4-benzodiazepin-2(3H)-on Click to Show/Hide
Disease Class	6B00-6B0Z: Anxiety disorder
Therapeutic Class	Antianxiety Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H12ClF3N2O
InChI	1S/C17H12ClF3N2O/c18-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)22-9-15(24)23(14)10-17(19,20)21/h1-8H,9-10H2
InChIKey	WYCLKVQLVUQKNZ-UHFFFAOYSA-N
Canonical SMILES	C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3)CC(F)(F)F
External Link
	Pubchem ID	31640
	CAS Number	23092-17-3
	CHEBI ID	5603
	TTD ID	D0Z9VB

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM009 Altered absorption (Unspecific) BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM076 Increased risk of prolong QT interval BM083 Potentiated the pharmacological effects (Unspecific) BM087 Antagonize the effect of antiepileptic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Halazepam
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0236		Calcium carbonate	CCaO3	10112	Minor		Inter Info	[183], [184], [185]
D0483		Didanosine	C10H12N4O3	135398739	Minor		Inter Info	[186], [183], [184], [187], [188], [185], [189], [190], [191]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[183], [184], [185]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[186], [183], [184], [187], [188], [185], [189], [190], [191]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[186], [183], [184], [187], [188], [185], [189], [190], [191]
D1480		Sodium bicarbonate	CHNaO3	516892	Minor		Inter Info	[186], [183], [184], [187], [188], [185], [189], [190], [191]
D1483		Sodium citrate	C6H5Na3O7	6224	Minor		Inter Info	[186], [183], [184], [187], [188], [185], [189], [190], [191]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1540		Teduglutide	C164H252N44O55S	16139605	Moderate		Inter Info	[156]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[70], [71], [72], [73], [74], [75], [76]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[135], [122], [136]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[40], [41]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[77], [78], [79], [80], [81]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [67], [90], [91], [92], [93]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[100], [101], [102]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [89], [67], [90], [91], [92], [93]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[109]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[40], [41], [124]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[137], [138]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[143], [144], [145], [146], [147]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[158]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[52], [160], [161], [162], [163]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[164], [165], [166]
	CYP450 enzyme induction					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[29], [47], [48]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[94], [95], [96]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[125], [126], [127], [128], [94], [129], [95], [96], [47], [130], [48], [131], [132]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[125], [126], [127], [128], [94], [129], [95], [96], [47], [130], [48], [131], [132]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[178], [179], [180], [181], [182]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[138], [194]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[178], [179], [180], [181], [182]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[154], [155]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[154], [155]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[154], [155]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[192], [193]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[148], [149], [150], [151], [152], [153]
	Additive CNS depression effects					Drug Num: 179
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[2], [3], [4]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[5], [6], [7], [8], [9], [10]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[11]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [1], [20], [21], [22], [23], [24], [25], [26]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[11]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[1]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[11]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[27], [28]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[29], [30], [31]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[32], [33], [7]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[37], [38], [39]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[37], [38], [39]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[42], [43]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[37], [38], [39]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[37], [38], [39]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[44], [7], [45]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[44], [7], [45]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[6], [7], [46]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[37], [38], [39]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[37], [38], [39]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[37], [38], [39]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[37], [38], [39]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[37], [38], [39]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[49], [50]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[37], [38], [39]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[37], [38], [39]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[37], [38], [39]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[37], [38], [39]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[37], [38], [39]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[37], [38], [39]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[37], [38], [39]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[37], [38], [39]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[37], [38], [39]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[37], [38], [39]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[37], [38], [39]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[37], [38], [39]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[37], [38], [39]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[37], [38], [39]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[97], [98], [99]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[37], [38], [39]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[37], [38], [39]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[44], [7], [45]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[37], [38], [39]
D0110		Articaine	C13H20N2O3S	32170	Moderate		Inter Info	[6], [7], [46]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[37], [38], [39]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[37], [38], [39]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[106]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[37], [38], [39]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[37], [38], [39]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[37], [38], [39]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[37], [38], [39]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[37], [38], [39]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[37], [38], [39]
D0319		Chloroprocaine	C13H19ClN2O2	8612	Moderate		Inter Info	[6], [7], [46]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[37], [38], [39]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[37], [38], [39]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[37], [38], [39]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[37], [38], [39]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[37], [38], [39]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[37], [38], [39]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[37], [38], [39]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[37], [38], [39]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[37], [38], [39]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[110], [111], [112]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[37], [38], [39]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[6], [113]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[37], [38], [39]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[37], [114], [115], [116], [117], [118], [119]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[37], [38], [39]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[37], [38], [39]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[37], [38], [39]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[120]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[37], [38], [39]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[133], [122], [134]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[37], [38], [39]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[37], [38], [39]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[139], [140], [141]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[37], [38], [39]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[142]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[37], [38], [39]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[37], [38], [39]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[49], [50]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[37], [38], [39]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[37], [38], [39]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[37], [38], [39]
D1004		Mepivacaine	C15H22N2O	4062	Moderate		Inter Info	[6], [7], [46]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[37], [38], [39]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[37], [38], [39]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[37], [38], [39]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[37], [38], [39]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[37], [38], [39]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[37], [38], [39]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[37], [38], [39]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[37], [38], [39]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[37], [38], [39]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[37], [38], [39]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[37], [38], [39]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[37], [38], [39]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[37], [38], [39]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[37], [38], [39]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[37], [38], [39]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[37], [38], [39]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[37], [38], [39]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[37], [38], [39]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[37], [38], [39]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[37], [38], [39]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[37], [38], [39]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[37], [38], [39]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[37], [38], [39]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[37], [38], [39]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[37], [38], [39]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[37], [38], [39]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[37], [38], [39]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[37], [38], [39]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[37], [38], [39]
D1561		Tetracaine	C15H24N2O2	5411	Moderate		Inter Info	[6], [7], [46]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[122], [157], [121]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[37], [38], [39]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[37], [38], [39]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[37], [38], [39]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[37], [38], [39]
D1675		Valerian	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[37], [38], [39]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[37], [38], [39]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[37], [38], [39]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[37], [38], [39]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[37], [38], [39]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[37], [38], [39]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[37], [38], [39]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[37], [38], [39]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[37], [38], [39]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[37], [38], [39]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[37], [38], [39]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[37], [38], [39]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[37], [38], [39]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[37], [38], [39]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[37], [38], [39]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[122], [159], [121]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[37], [38], [39]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[37], [38], [39]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[37], [38], [39]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[37], [38], [39]
D1337		Prilocaine	C13H20N2O	4906	Moderate		Inter Info	[6], [7], [46]
D1344		Procaine	C13H20N2O2	4914	Moderate		Inter Info	[6], [7], [46]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[37], [38], [39]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[37], [38], [39]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[37], [38], [39]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[37], [38], [39]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[37], [38], [39]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[6], [7], [46]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[37], [38], [39]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[37], [38], [39]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[37], [38], [39]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[37], [38], [39]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[37], [38], [39]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[37], [38], [39]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[37], [38], [39]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[37], [38], [39]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[37], [38], [39]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[37], [38], [39]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[37], [38], [39]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[37], [38], [39]
D0994		Melatonin	C13H16N2O2	896	Minor		Inter Info	[6], [135], [122]
	Additive hypotensive effects					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[34], [35], [36]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[34], [35], [36]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[34], [35], [36]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[34], [35], [36]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[34], [35], [36]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[34], [35], [36]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[34], [35], [36]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[34], [35], [36]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[34], [35], [36]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[34], [35], [36]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[34], [35], [36]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[34], [35], [36]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[34], [35], [36]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[34], [35], [36]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[34], [35], [36]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[34], [35], [36]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[34], [35], [36]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[34], [35], [36]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[34], [35], [36]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[34], [35], [36]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[34], [35], [36]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[34], [35], [36]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[34], [35], [36]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[34], [35], [36]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[34], [35], [36]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[34], [35], [36]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[34], [35], [36]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[34], [35], [36]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[172], [173], [174], [175], [176], [177]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[104], [167], [168]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[29], [107], [108]
D1785		Flumazenil	C15H14FN3O3	3373	Moderate		Inter Info	[121], [122], [123]
D0544		Dyphylline	C10H14N4O4	3182	Minor		Inter Info	[169], [170], [171]
D0064		Aminophylline	C16H24N10O4	9433	Minor		Inter Info	[169], [170], [171]
D1570		Theophylline	C7H8N4O2	2153	Minor		Inter Info	[169], [170], [171]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[103], [104], [105]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[103], [104], [105]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[103], [104], [105]

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155	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
156	Product Information. Gattex (teduglutide). NPS Pharmaceuticals, Bedminster, NJ.
157	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
158	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
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175	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
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