Drug General Information (ID: DDIWI3GUER)
Drug Name			Halazepam		Drug Info		Amiodarone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antianxiety Agents				Antiarrhythmic Agents
Structure

Mechanism of Halazepam-Amiodarone Interaction (Severity Level: Minor)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Halazepam				Amiodarone
Mechanism 1		Benzodiazepines				Increase the pharmacologic effects of benzodiazepines
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Halazepam and Amiodarone
Mechanism 2		Benzodiazepine				Increase the pharmacologic effects of benzodiazepines
Key Mechanism Factor 2
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Halazepam and Amiodarone

References
1	Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23. [PMID: 2661600]
2	Nolan PE, Marcus FI, Karol MD, Hoyer GL, Gear K "Effect of phenytoin on the clinical pharmacokinetics of amiodarone." J Clin Pharmacol 30 (1990): 1112-9. [PMID: 2273084]
3	Product Information. Niravam (alprazolam). Schwarz Pharma, Mequon, WI.
4	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
5	Product Information. Xanax XR (alprazolam). Pfizer U.S. Pharmaceuticals Group, New York, NY.
6	Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71. [PMID: 1985357]