Drug General Information (ID: DDIKT0HBXF)
Drug Name			Halazepam		Drug Info		Kava		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antianxiety Agents				Herbal Products
Structure

Mechanism of Halazepam-Kava Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Halazepam				Kava
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Halazepam and Kava

Recommended Action
Management		Until further information is available, concomitant use of kava and benzodiazepines is not recommended. Patients on benzodiazepines should be advised to consult their caregiver before using any alternative medicines.

References
1	Almeida JC, Grimsley EW "Coma from the health food store: interaction between kava and alprazolam." Ann Intern Med 125 (1996): 940-1. [PMID: 8967683]
2	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
3	Pepping J "Kava: Piper methysticum." Am J Health Syst Pharm 56 (1999): 957-60. [PMID: 10365719]