Details of Drug

Drug General Information (ID: D0656)
Drug Name	Fexofenadine
Drug Type	Small molecule
Drug Synonymous	Carboxyterfenadine; Fexofendine; Terfenadine acid metabolite; Terfenadine carboxylate; F 9427; MDL 16455; Allegra (TN); Fastofen (TN); Fexofenadine (INN); Fexofenadine [INN:BAN]; Telfast (TN); Terfenadine-COOH; Terfenidine carboxylate, MDL 16455; Tilfur (TN); 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid Click to Show/Hide
Disease Class	CA08: Vasomotor/allergic rhinitis
Therapeutic Class	Antiallergic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C32H39NO4
InChI	1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
InChIKey	RWTNPBWLLIMQHL-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
External Link
	Pubchem ID	3348
	CAS Number	83799-24-0
	CHEBI ID	5050
	TTD ID	D01KPV
	VARIDT ID	DR00026

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM010 Transporter inhibition BM011 Transporter induction BM014 Interference of cell/tissue uptake BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Fexofenadine
Affected gastrointestinal absorption
	Complex formation					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[1]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[1]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[1]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2], [9]
Affected cellular transport
	Transporter inhibition					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0155		Bempedoic acid	C19H36O5	10472693	Moderate		Inter Info	[4], [5]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[6]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[2], [7], [8]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[12]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[2], [13]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[2], [14]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[15]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[16], [17], [18], [19], [20]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[18], [21]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[2], [22]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[18], [2], [23]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[26]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[27]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[28]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[18], [2], [29]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[2], [30]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[2], [33]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[36]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[37]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[38]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[39]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[40]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[41]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[43]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[48]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[18], [2], [49], [50]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[51]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[1], [52]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[1], [52]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[1], [52]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[1], [52]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[1], [52]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[1], [52]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[1], [52]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[1], [52]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[1], [52]
	Transporter induction					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[2], [3]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[24], [18], [2], [25]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[2], [42]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[45], [46], [47]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[56], [57]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[34], [10], [35]
Pharmacodynamic antagonistic effects
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[9], [10], [11]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[9], [10], [11]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1807		Histamine	C5H9N3	774	Moderate		Inter Info	[31], [10], [32]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2], [44], [10]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[53], [54], [55]

References
1	Product Information. Allegra (fexofenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
4	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
5	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
6	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
7	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
8	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
9	Multum Information Services, Inc. Expert Review Panel.
10	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
11	NLM. National Library of Medicine. NIH. National Institutes of Health "Trichophyton for intradermal skin testing (trichophyton mentagrophytes and trichophyton rubrum) injection.".
12	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
13	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
14	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
15	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
16	Allred AJ, Bowen CJ, Park JW, et al. "Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers." Br J Clin Pharmacol 72 (2011): 321-9. [PMID: 21434975]
17	Canadian Pharmacists Association.
18	Cerner Multum, Inc. "Australian Product Information.".
19	Kalliokoski A, Niemi M "Impact of OATP transporters on pharmacokinetics." Br J Pharmacol 158 (2009): 693-705. [PMID: 19785645]
20	Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
21	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
22	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
23	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
24	Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
25	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
26	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
27	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
28	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
29	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
30	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
31	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
32	Product Information. Histatrol (histamine phosphate). Center Laboratories, Port Washington, NY.
33	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
34	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
35	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
36	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
37	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
38	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
39	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
40	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
41	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
42	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
43	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
44	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
45	Bailey DG, Dresser GK, Munoz C, Freemar DJ, Kim RB "Reduction of fexofenadine bioavailability by fruit juices." Clin Pharmacol Ther 69 (2001): PI-82. [PMID: 15735611]
46	Dresser GK, Bailey DG, Leake BF, et al. "Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine." Clin Pharmacol Ther 71 (2002): 11-20. [PMID: 11823753]
47	Hamman MA, Bruce MA, HaehnerDaniels BD, Hall SD "The effect of rifampin administration on the disposition of fexofenadine." Clin Pharmacol Ther 69 (2001): 114-21. [PMID: 11240975]
48	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
49	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
50	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
51	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
52	Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
53	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
54	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
55	Product Information. Vitrase (hyaluronidase). Bausch and Lomb, Rochester, NY.
56	Dresser GK, Schwarz UI, Wilkinson GR, Kim RB "Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects." Clin Pharmacol Ther 73 (2003): 41-50. [PMID: 12545142]
57	Wang Z, Hamman MA, Huang SM, Lesko LJ, Hall SD "Effect of St John's wort on the pharmacokinetics of fexofenadine." Clin Pharmacol Ther 71 (2002): 414-20. [PMID: 12087344]

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