Drug General Information (ID: DDIS352WAR)
Drug Name			Fexofenadine		Drug Info		Aluminum hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiallergic Agents				Antacids
Structure

Mechanism of Fexofenadine-Aluminum hydroxide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Fexofenadine				Aluminum hydroxide
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Aluminum hydroxide due to formation of complexes caused by Fexofenadine

Recommended Action
Management		Fexofenadine should be administered at least 2 hours before antacids.

References
1	Product Information. Allegra (fexofenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.