Drug General Information (ID: DDIXS6B0VN)
Drug Name			Fexofenadine		Drug Info		Pitolisant		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiallergic Agents				Cns Stimulants
Structure

Mechanism of Fexofenadine-Pitolisant Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Fexofenadine				Pitolisant
Mechanism		Decrease central histamine effects				Increase central histamine effects
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Fexofenadine when combined with Pitolisant

Recommended Action
Management		According to the manufacturer, coadministration of pitolisant with centrally acting H1-receptor antagonists or tri- and tetracyclic antidepressants should be avoided.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
3	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]