Details of Drug

Drug General Information (ID: D0644)
Drug Name	Fenoldopam
Drug Type	Small molecule
Drug Synonymous	Carlacor; Fenoldopamum; Fenodopam mesylate; Fenoldopamum [Latin]; SKF 82526; Carlacor (TN); Corlopam (TN); Fenoldopam (INN);Fenoldopam [INN:BAN]; SKF 82526-J; SKF-82526J; SK&F-82526; 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C16H16ClNO3
InChI	1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
InChIKey	TVURRHSHRRELCG-UHFFFAOYSA-N
Canonical SMILES	C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
External Link
	Pubchem ID	3341
	CAS Number	67227-56-9
	CHEBI ID	5002
	TTD ID	D0R6BI

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM065 Increased risk of hypokalemia BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM089 Antagonize the effect of antihypertensive agents BM103 Antagonize the renal vasodilatory effect BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Fenoldopam
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1825		Ioflupane I-123	C18H23FINO2	3086674	Moderate		Inter Info	[50], [51], [52]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[3], [4], [65]
	Additive hypotensive effects					Drug Num: 214
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[17]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[19]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[15], [20]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[21], [22], [23]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[15], [20]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[21], [22], [23]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[15], [20]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[21], [22], [23]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[24], [25], [26]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[20]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[21], [22], [23]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[15], [20]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[15], [20]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[15], [20]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[20]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[20]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[20]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[28], [29], [30]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[28], [29], [30]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[21], [22], [23]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[21], [22], [23]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[21], [22], [23]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[20]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[20]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[21], [22], [23]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[15], [20]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[21], [22], [23]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[21], [22], [23]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[15], [20]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[21], [22], [23]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[3], [41], [42]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[15], [20]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[15], [20]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[21], [22], [23]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[15], [20]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[20]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[21], [22], [23]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[20]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[15], [20]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[35], [36], [38]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[24], [15], [43]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[28], [29], [30]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[44], [45], [46]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[15], [20]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[21], [22], [23]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[15], [20]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0213		Bromotheophylline	C7H7BrN4O2	11808	Moderate		Inter Info	[15], [20]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[15], [20]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[21], [22], [23]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[3], [4], [47]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[15], [20]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[20]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[21], [22], [23]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[21], [22], [23]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[15], [20]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[21], [22], [23]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[15], [20]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[21], [22], [23]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[21], [22], [23]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[3], [4], [47]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[15], [20]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[21], [22], [23]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[21], [22], [23]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[15], [20]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[21], [22], [23]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[15], [20]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[21], [22], [23]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[21], [22], [23]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[21], [22], [23]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[3], [4], [47]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[4], [48], [49]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[15], [20]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[15], [20]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[21], [22], [23]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[15], [20]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[15], [20]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[15], [20]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[21], [22], [23]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[15], [20]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[15], [20]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[21], [22], [23]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[4], [48], [49]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[15], [20]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[15], [20]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[15], [20]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[20]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[20]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[4], [69], [70]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[21], [22], [23]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[71]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[21], [22], [23]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[15], [20]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[20]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[20]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[20]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[51], [72], [70]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[73]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[15], [20]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[74], [75], [76]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[21], [22], [23]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[21], [22], [23]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[21], [22], [23]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[21], [22], [23]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[20]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[77]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[15], [20]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[20]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[15], [20]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[21], [22], [23]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[15], [20]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[21], [22], [23]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[78]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[4], [48], [49]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[21], [22], [23]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[15], [20]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[15], [20]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[21], [22], [23]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[15], [20]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[15], [20]
D1668		Urea	CH4N2O	1176	Moderate		Inter Info	[15], [20]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[44], [45], [46]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[21], [22], [23]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[21], [22], [23]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[15], [20]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[15], [20]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[15], [20]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[15], [20]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[15], [20]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[15], [20]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[20]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[15], [20]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[21], [22], [23]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[15], [20]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[15], [20]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[15], [20]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[21], [22], [23]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[15], [20]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[15], [20]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[20]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[15], [20]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[21], [22], [23]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[15], [20]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[21], [22], [23]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[15], [20]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[21], [22], [23]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[15], [20]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[15], [20]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[15], [20]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[15], [20]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[21], [22], [23]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[15], [20]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[15], [20]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[15], [20]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[15], [20]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[20]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[21], [22], [23]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[15], [20]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[15], [20]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[20]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[15], [20]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[21], [22], [23]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[20]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[20]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[15], [20]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[15], [20]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [15], [63], [64]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[21], [22], [23]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[4], [48], [49]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[15], [20]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[31], [32], [33], [34], [35], [18], [36], [37], [38], [39], [40]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[21], [22], [23]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[15], [20]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[15], [20]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[21], [22], [23]
D0711		Garlic	NA	NA	Minor		Inter Info	[81], [82]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[83], [84]
	Increased risk of hypokalemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[66], [67], [68]
	Increased risk of ventricular arrhythmias					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[2], [3], [4], [5], [6], [7]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[8], [9]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[10], [11]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[12]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[13], [14], [15]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[16]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[18]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[4], [27]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[4], [27]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[4], [27]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[4], [27]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[4], [27]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[4], [27]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[4], [27]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[4], [27]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[4], [27]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[4], [27]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[4], [27]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[4], [27]
	Antagonize the renal vasodilatory effect					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[80]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[79], [15]

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