Details of Drug-Drug Interaction
| Drug General Information (ID: DDI1Y7MPCB) | |||||||||
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| Drug Name | Mecamylamine | Drug Info | Fenoldopam | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antihypertensive Agents | Antihypertensive Agents | |||||||
| Structure | |||||||||
| Mechanism of Mecamylamine-Fenoldopam Interaction (Severity Level: Moderate) | |||||||||
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| Additive hypotensive effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Mecamylamine | Fenoldopam | |||||||
| Mechanism |
Hypotensive effects Neuronal acetylcholine receptor Antagonist |
Antihypertensive agent Dopamine D1 receptor Agonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Neuronal acetylcholine receptor | Structure Sequence | |||||||
| Protein Family | Ligand-gated ion channel (TC 1.A.9) family | ||||||||
| Protein Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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| Key Mechanism Factor 2 | |||||||||
| Factor Name | Dopamine D1 receptor |
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Structure
Sequence
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
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| Gene Name | DRD1 | ||||||||
| Uniprot ID | DRD1_HUMAN | ||||||||
| KEGG Pathway | hsa:1812 | ||||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is strongly advised during concurrent use. Inpatient monitoring of the heart rate and blood pressure is recommended. Sublingual nitroglycerin has been used safely with fenoldopam. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON. | ||||||||||||||||||
| 2 | Product Information. Corlopam (fenoldopam). Neurex, Menlo Park, CA. | ||||||||||||||||||