Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI5ZVNHUT)
  Drug Name Fenoldopam Drug Info Nesiritide Drug Info
  Drug Type Small molecule Hormones
  Therapeutic Class Antihypertensive Agents Recombinant Natriuretic Peptide
  Structure

 Mechanism of Fenoldopam-Nesiritide Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Fenoldopam Nesiritide
      Mechanism Antihypertensive agent
Dopamine D1 receptor  Agonist 		Antihypertensive agent
Guanylate cyclase  Agonist
      Key Mechanism Factor 1
Factor Name Dopamine D1 receptor
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Structure Sequence
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
Gene Name DRD1
Uniprot ID DRD1_HUMAN
KEGG Pathway hsa:1812
Protein Family G-protein coupled receptor 1 family
Protein Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Guanylate cyclase soluble Structure Sequence
Protein Family Adenylyl cyclase class-4/guanylyl cyclase family
Protein Function
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Fenoldopam and Nesiritide 

Recommended Action
      Management Whether used alone or with other agents, nesiritide should be administered only in settings where blood pressure can be closely monitored. The dosage should be reduced or the drug discontinued in patients who develop hypotension.

References
1 Product Information. Natrecore (nesiritide) Scios Inc, Sunnyvale, CA.