Drug General Information (ID: DDIRN0IHMV)
  Drug Name Cyclosporine Drug Info Fenoldopam Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiviral Agents Antihypertensive Agents
  Structure

 Mechanism of Cyclosporine-Fenoldopam Interaction (Severity Level: Minor)
     Antagonize the renal vasodilatory effect Click to Show/Hide Mechanism Graph
      Drug Name Cyclosporine Fenoldopam
      Mechanism Renal vasoconstriction Renal vasodilation
      Key Mechanism Factor 1
Factor Name Renal vasodilatory effect
Factor Description The beneficial effects of renal vasodilators may be reduced, leading to renal vasoconstriction and reduced renal blood flow, which may lead to chronic nephrotoxicity.
      Mechanism Description
  • Antagonize the renal vasodilatory effect of Cyclosporine when combined with Fenoldopam 

References
1 Jorkasky DK, Audet P, Shusterman N, Ilson B, Dafoe D, Hedrich D, Stote RM "Fenoldopam reverses cyclosporine-induced renal vasoconstriction in kidney transplant recipients." Am J Kidney Dis 19 (1992): 567-72. [PMID: 1350709]