Details of Drug

Drug General Information (ID: D0621)
Drug Name	Ethotoin
Drug Type	Small molecule
Drug Synonymous	Accenon; Ethotoine; Ethotoinum; Etotoina; Peganone; Pegoanone; Abbott brand of ethotoin; Accenon (TN); Ethotoine [INN-French]; Ethotoinum [INN-Latin]; Etotoina [INN-Spanish]; Peganone (TN); Ethotoin [INN:BAN:JAN]; Ethotoin (JAN/USP/INN); (+-)-3-Ethyl-5-phenylhydantoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; 3-ethyl-5-phenylimidazolidine-2,4-dione Click to Show/Hide
Disease Class	8A61-8A6Z: Epilepsy/seizure
Therapeutic Class	Anticonvulsants
Structure
Structure	3D Structure		2D Structure
Formula	C11H12N2O2
InChI	1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
InChIKey	SZQIFWWUIBRPBZ-UHFFFAOYSA-N
Canonical SMILES	CCN1C(=O)C(NC1=O)C2=CC=CC=C2
External Link
	Pubchem ID	3292
	CAS Number	86-35-1
	CHEBI ID	4888
	TTD ID	D05EPM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM026 Increased metabolism (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM043 Additive immunosuppressive effects BM045 Additive neuromuscular blocking effects BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM087 Antagonize the effect of antiepileptic agents BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Ethotoin
Affected gastrointestinal absorption
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [125], [160], [161], [162], [163], [164], [165], [166]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[251], [252]
D0360		Clofibrate	C12H15ClO3	2796	Minor		Inter Info	[32], [1], [259]
D1095		Mycophenolic acid	C17H20O6	446541	Minor		Inter Info	[263]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Minor		Inter Info	[263]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[30], [31], [32], [1], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[93], [94], [95], [96], [97], [98]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[94], [95], [98]
D0315		Chloramphenicol (otic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[94], [95], [98]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[175], [32], [1], [176], [177], [178]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[32], [1], [193], [194], [195], [196], [197]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[208]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[223], [224], [225]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[226], [117]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[242], [243], [244]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[249], [250]
	CYP450 enzyme induction					Drug Num: 61
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[105], [106]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[54], [56], [57]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[32], [1], [127], [128], [129], [130], [131], [132], [133], [134], [135]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[141], [22], [32], [1], [142]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[167], [168], [169], [170]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[136], [137], [138]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[66], [67]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[141], [22], [32], [1], [142]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[67], [182], [183], [68], [184], [185]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[54], [56], [57]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[32], [1], [40], [198]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[32], [1], [40], [198]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[203], [204], [205], [206], [207]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[32], [105], [106]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[105], [106]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[168], [169], [170]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[105], [106]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[203], [205], [207]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[32], [105], [106]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[213], [214], [215]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[54], [56], [57]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[216], [217], [218]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[220]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[32], [1], [142]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[32], [105], [106]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[234], [235]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[237]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[239]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[216], [217], [218]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[105], [106]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[167], [168], [169], [170]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[264]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[253], [71]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[247], [248]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[200], [201], [202]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 161
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[3], [4], [5]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[28], [29]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[63], [64], [65]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[63], [64], [65]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[72], [73]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[63], [64], [65]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[63], [64], [65]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[82], [1], [83]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[63], [64], [65]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[63], [64], [65]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[63], [64], [65]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[63], [64], [65]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[63], [64], [65]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[63], [64], [65]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[91], [92]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[63], [64], [65]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[63], [64], [65]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[63], [64], [65]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[63], [64], [65]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[63], [64], [65]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[63], [64], [65]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[63], [64], [65]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[63], [64], [65]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[63], [64], [65]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[63], [64], [65]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[63], [64], [65]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[63], [64], [65]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[63], [64], [65]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[63], [64], [65]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[63], [64], [65]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[63], [64], [65]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[63], [64], [65]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[82], [1], [83]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[63], [64], [65]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[63], [64], [65]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[63], [64], [65]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[173]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[63], [64], [65]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[63], [64], [65]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[63], [64], [65]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[63], [64], [65]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[63], [64], [65]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[63], [64], [65]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[63], [64], [65]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[63], [64], [65]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[63], [64], [65]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[63], [64], [65]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[63], [64], [65]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[63], [64], [65]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[63], [64], [65]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[63], [64], [65]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[63], [64], [65]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[63], [64], [65]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[63], [64], [65]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[63], [64], [65]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[63], [64], [65]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[63], [64], [65]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[63], [64], [65]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[32], [179]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[63], [64], [65]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[32], [1], [40], [180], [181]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[63], [64], [65]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[63], [64], [65]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[63], [64], [65]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[63], [64], [65]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[63], [64], [65]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[63], [64], [65]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[63], [64], [65]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[63], [64], [65]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[199]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[63], [64], [65]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[63], [64], [65]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[91], [92]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[63], [64], [65]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[63], [64], [65]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[63], [64], [65]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[63], [64], [65]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[63], [64], [65]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[63], [64], [65]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[63], [64], [65]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[63], [64], [65]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[63], [64], [65]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[63], [64], [65]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[63], [64], [65]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[63], [64], [65]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[63], [64], [65]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[210], [211], [212]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[63], [64], [65]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[63], [64], [65]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[63], [64], [65]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[63], [64], [65]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[63], [64], [65]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[63], [64], [65]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[63], [64], [65]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[63], [64], [65]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[63], [64], [65]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[63], [64], [65]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[63], [64], [65]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[63], [64], [65]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[63], [64], [65]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[63], [64], [65]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[63], [64], [65]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[63], [64], [65]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[63], [64], [65]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[63], [64], [65]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[63], [64], [65]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[63], [64], [65]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[63], [64], [65]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[63], [64], [65]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[63], [64], [65]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[63], [64], [65]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[63], [64], [65]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[63], [64], [65]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[210], [212], [219]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[63], [64], [65]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[63], [64], [65]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[63], [64], [65]
D1675		Valerian	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[63], [64], [65]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[63], [64], [65]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[63], [64], [65]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[63], [64], [65]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[63], [64], [65]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[63], [64], [65]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[63], [64], [65]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[63], [64], [65]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[63], [64], [65]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[63], [64], [65]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[63], [64], [65]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[63], [64], [65]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[63], [64], [65]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[63], [64], [65]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[63], [64], [65]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[63], [64], [65]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[63], [64], [65]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[63], [64], [65]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[63], [64], [65]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[63], [64], [65]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[63], [64], [65]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[63], [64], [65]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[63], [64], [65]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[63], [64], [65]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[63], [64], [65]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[63], [64], [65]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[63], [64], [65]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[63], [64], [65]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[63], [64], [65]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[63], [64], [65]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[63], [64], [65]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[63], [64], [65]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[63], [64], [65]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[63], [64], [65]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[63], [64], [65]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[63], [64], [65]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[63], [64], [65]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[63], [64], [65]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[63], [64], [65]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[63], [64], [65]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[63], [64], [65]
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[43], [32], [45]
	Additive immunosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[49]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[209]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[222]
	Additive neuromuscular blocking effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[32], [240], [241]
	Increased risk of bleeding					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[136], [137], [138]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[254], [136], [137], [255], [138], [256], [257], [258]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[22], [23], [24]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[25]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[27]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[22], [23], [24]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[74], [32], [75]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[126]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[139], [140]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[171]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[172]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[74], [32], [75]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1], [174]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[192]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [221]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[230], [231], [232], [233]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[230], [231], [232], [233]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[1], [236]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[238]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[245], [246]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1805		Hepatitis B Immune Globulin	NA	NA	Moderate		Inter Info	[189], [190], [191]
D1809		Human rabies virus immune globulin	NA	NA	Moderate		Inter Info	[189], [190], [191]
D1810		Human vaccinia virus immune globulin	NA	NA	Moderate		Inter Info	[189], [190], [191]
D1811		Human Varicella-Zoster Immune Globulin	NA	NA	Moderate		Inter Info	[189], [190], [191]
D1903		Tetanus Immune Globulin	NA	NA	Moderate		Inter Info	[189], [190], [191]
D0940		Lithium carbonate	CLi2O3	11125	Minor		Inter Info	[260], [261], [262]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[32], [1], [99], [100], [101]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[102], [103], [104]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[32], [1], [99], [100], [101]
D1832		Levoleucovorin	C20H23N7O7	135398559	Moderate		Inter Info	[200], [201], [202]
D1833		Levomefolic acid	C20H25N7O6	135398561	Moderate		Inter Info	[200], [201], [202]
D1834		Levomefolic acid (calcium)	C20H25N7O6	135398561	Moderate		Inter Info	[200], [201], [202]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1], [227], [228], [229]
D1830		Leucovorin	C20H23N7O7	135403648	Moderate		Inter Info	[200], [201], [202]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [1], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[186], [187], [188]

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115	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
116	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
117	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
118	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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