Drug General Information (ID: DDIFCEVG9U)
Drug Name			Ethotoin		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Antimanic Agents
Structure

Mechanism of Ethotoin-Lithium carbonate Interaction (Severity Level: Minor)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ethotoin				Lithium carbonate
Mechanism		Increase the toxic effects of lithium carbonate				Lithium carbonate
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Ethotoin and Lithium carbonate

Recommended Action
Management		Patients who must take both drugs should be monitored for evidence of lithium toxicity. Other hydantoins may interact with lithium in a similar manner.

References
1	Speirs J, Hirsch SR "Severe lithium toxicity with "normal" serum concentrations." Br Med J 1 (1978): 815-6
2	Minhaj FS, Anderson BD, King JD, Leonard JB. Outcomes of acute exploratory pediatric lithium ingestions. Clin Toxicol (Phila). 2020 Sep;58(9):881-885.
3	MacCallum WA "Interaction of lithium and phenytoin." Br Med J 280 (1980): 610-1