Details of Drug

Drug General Information (ID: D0551)
Drug Name	Edoxaban
Drug Type	Small molecule
Drug Synonymous	EDOXABAN; 480449-70-5; SAVAYSA; 912273-65-5; DU-176; UNII-NDU3J18APO; DU-176b; NDU3J18APO; N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide; CHEMBL1269025; CHEBI:85973; 480449-70-5 (free base); C24H30ClN7O4S; Edoxaban [USAN:INN]; Edoxaban (USAN/INN); SCHEMBL330046; AMY508; GTPL7575; HSDB 8406; DTXSID50197398; AOB87348; EX-A5582; BDBM50328731; MFCD13195544; s4429; ZINC43200832; AKOS005146069; CS-1331; DB09075; NCGC00378907-01; NCGC00378907-02; NCGC00378907-03; AS-35107; HY-10264; N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydro(1,3)thiazolo(5,4-c)pyridine-2-carboxamido)cyclohexyl)oxamide; QC-10007; X1006; X3723; D09710; 449E705; A860576; Q21011234; Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-((1S,2R,4S)-4- ((dimethylamino)carbonyl)- 2-(((4,5,6,7-tetrahydro-5-methylthiazolo(5,4-c)pyridin-2-yl)carbonyl)amino)cyclohexyl)-; N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide; N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide; N(1)-(5-chloropyridin-2-yl)-N(2)-{(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl}ethanediamide; N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide; N-(5-Chloro-2-pyridinyl)-N'-[4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide;; N-(5-chloropyridin-2-yl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide; N-(5-Chloropyridin-2-yl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide; N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl) ethanediamide; N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide; N1-(5-Chloropyridin-2-yl)-N2-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide Click to Show/Hide
Therapeutic Class	Anticoagulants/Factor Xa Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C24H30ClN7O4S
InChI	InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1
InChIKey	HGVDHZBSSITLCT-JLJPHGGASA-N
Canonical SMILES	CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C
External Link
	Pubchem ID	10280735
	INTEDE ID	DR0558
	VARIDT ID	DR00166

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM050 Increased risk of bleeding BM085 Antagonize the effect of antithrombotic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Edoxaban
Affected cellular transport
	Transporter inhibition					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[2], [3], [4], [1]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[2], [3], [4], [1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[2], [3], [4], [1]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[2], [3], [4], [1]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[2], [3], [4], [1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[2], [3], [4], [1]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[2], [3], [4], [1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2], [3], [4], [1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[16], [17], [18]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2], [3], [4], [1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [3], [4], [1]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[2], [3], [4], [1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2], [3], [4], [1]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2], [3], [4], [1]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Major		Inter Info	[2], [3], [4], [1]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[2], [3], [4], [1]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[2], [3], [4], [1]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[2], [3], [4], [1]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[2], [3], [4], [1]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Major		Inter Info	[2], [3], [1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[2], [3], [4], [1]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[2], [3], [4], [1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[2], [3], [4], [1]
D1445		Sarecycline	C24H29N3O8	54681908	Major		Inter Info	[2], [3], [4], [1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[2], [3], [4], [1]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[2], [3], [1]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Major		Inter Info	[2], [3], [1]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[2], [3], [4], [1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2], [3], [4], [1]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[2], [3], [4], [1]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[2], [3], [4], [1]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[2], [3], [4], [1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[2], [3], [4], [1]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[2], [3], [4], [1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2], [3], [4], [1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[2], [3], [4], [1]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Major		Inter Info	[2], [3], [1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[2], [3], [4], [1]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[2], [3], [4], [1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2], [3], [4], [1]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[2], [3], [4], [1]
D1348		Progesterone	C21H30O2	5994	Major		Inter Info	[2], [3], [4], [1]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[2], [3], [4], [1]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[2], [3], [4], [1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[2], [3], [4], [1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[14], [30], [2], [41], [42], [43], [44], [1], [18], [45], [46], [47]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[2], [3], [4], [1]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[2], [3], [4], [1]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[2], [3], [4], [1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[2], [3], [4], [1]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[2], [3], [4], [1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[2], [3], [4], [1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[2], [3], [4], [1]
D1664		Ulipristal	C28H35NO3	13559281	Major		Inter Info	[2], [3], [4], [1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[2], [3], [4], [1]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [3], [4], [1]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[2], [118], [119]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[2], [121]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[122]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[2], [141]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[170]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[14], [2], [177], [178]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[142], [143], [144]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[123]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2], [149]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 144
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1]
D0047		Alteplase	NA	NA	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[12]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[2], [13]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[14], [2], [15]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0415		Danaparoid	NA	NA	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[19]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[20], [21]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[2], [22]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[23], [24], [1]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[25]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[1]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [26]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1]
D0462		Dextran (-1)	C18H32O16	4125253	Major		Inter Info	[1]
D0463		Dextran (high molecular weight)	C18H32O16	4125253	Major		Inter Info	[1]
D0464		Dextran (low molecular weight)	C18H32O16	4125253	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [20], [27]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[20]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[28]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[29], [30], [2], [31]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1]
D0841		Ipilimumab	NA	NA	Major		Inter Info	[23], [2], [32]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[33], [34]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[20], [35]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[14], [2], [36]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[37]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[38]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2], [39], [40]
D1395		Reteplase	NA	NA	Major		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[48]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[49]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[50]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1]
D1613		Tositumomab	NA	NA	Major		Inter Info	[51], [52]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[51], [52]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[14], [2], [53]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1]
D1669		Urokinase	NA	NA	Major		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[54]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[55], [14], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[55], [14], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[66], [67], [68], [69], [70], [71], [72], [73]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[74]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[75]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[20], [76]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[115], [116], [117]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[55], [14], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[66], [67], [68], [69], [70], [71], [72], [73]
D0711		Garlic	NA	NA	Moderate		Inter Info	[124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[129], [139], [140], [133], [136]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[145]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2], [146]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[2], [147], [148]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[68], [69], [73]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[150], [151], [152]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[115], [116], [117]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[153], [154], [155], [156], [126], [157], [158], [127], [129], [130], [159], [139], [160], [133], [161], [162], [163], [136], [164]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[165], [127], [129], [166], [130], [167], [133], [136], [168]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[169]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[2], [147], [148]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[115], [116], [117]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[115], [116], [117]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[55], [14], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[20], [171]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[172], [173]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[74]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[68], [69], [73]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[66], [67], [68], [69], [70], [71], [72], [73]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1894		Sugammadex	C72H112O48S8	6918585	Moderate		Inter Info	[2], [174]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[2], [175], [176]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[115], [116], [117]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[74]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[150], [181], [2], [182], [183], [184], [185], [129], [186], [187], [188], [189], [190], [191], [192], [151], [193], [194], [152], [195]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[77], [78], [79], [80], [14], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0253		Capsicum	NA	NA	Minor		Inter Info	[129]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[129], [196], [133]
D0368		Clove	NA	NA	Minor		Inter Info	[129], [197], [198], [199]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[200], [129], [201]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0373		Coagulation factor X human	NA	NA	Moderate		Inter Info	[120]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[179], [180]

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