Drug General Information (ID: DDIZWE26KO)
Drug Name			Collagenase clostridium histolyticum		Drug Info		Edoxaban		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Collagenase Enzyme				Anticoagulants/Factor Xa Inhibitors

Mechanism of Collagenase clostridium histolyticum-Edoxaban Interaction (Severity Level: Moderate)
Increased risk of bleeding Click to Show/Hide Mechanism Graph
Drug Name		Collagenase clostridium histolyticum				Edoxaban
Mechanism		Risk of bleeding Antiplatelet/anticoagulant effects				Risk of bleeding Anticoagulant
Key Mechanism Factor 1
		Factor Name		Bleeding
		Factor Description		Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc.
Mechanism Description		Increased risk of bleeding by the combination of Collagenase clostridium histolyticum and Edoxaban

Recommended Action
Management		Collagenase clostridium histolyticum should be used with caution in patients receiving or within 7 days of receiving anticoagulants (except for low-dose aspirin), platelet inhibitors, or thrombolytic agents.

References
1	Product Information. Xiaflex (collagenase clostridium histolyticum). Auxilium Pharmaceuticals Inc, Norristown, PA.