Details of Drug

Drug General Information (ID: D0384)
Drug Name	Collagenase clostridium histolyticum
Drug Type	Protein/peptide
Drug Synonymous	Xiaflex (TN) Click to Show/Hide
Disease Class	4B20: Sarcoidosis
Therapeutic Class	Collagenase Enzyme
External Link
External Link	TTD ID	D0I4ZQ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM050 Increased risk of bleeding
Relation Graph

Full list of drugs interacting with Collagenase clostridium histolyticum
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0047		Alteplase	NA	NA	Moderate		Inter Info	[1]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[1]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[2], [3], [1]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[1]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[2], [3], [1]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[2], [3], [1]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[1]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[1]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[1]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[1]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[1]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[1]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[2], [3], [1]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[1]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[1]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[1]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[1]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[1]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[1]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[1]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[1]

References
1	Product Information. Xiaflex (collagenase clostridium histolyticum). Auxilium Pharmaceuticals Inc, Norristown, PA.
2	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
3	Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]

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