Details of Drug

Drug General Information (ID: D0537)
Drug Name	Drotrecogin alfa
Drug Type	Protein/peptide
Drug Synonymous	Xigris; Drotrecogin alfa (activated); Xigris (TN); Drotrecogin alfa (activated) (USAN) Click to Show/Hide
Disease Class	8B1Z: Cerebral ischaemia; 1G40-1G41: Sepsis
Therapeutic Class	Coagulation Modifiers
External Link
External Link	TTD ID	D0PG0G

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects BM014 Interference of cell/tissue uptake BM050 Increased risk of bleeding
Relation Graph

Full list of drugs interacting with Drotrecogin alfa
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[71], [72], [73]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 128
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1]
D0047		Alteplase	NA	NA	Major		Inter Info	[1]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[1]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[2], [3], [4]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [2], [7], [3], [4], [8]
D0415		Danaparoid	NA	NA	Major		Inter Info	[2], [3], [4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[9], [10]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[11]
D0462		Dextran (-1)	C18H32O16	4125253	Major		Inter Info	[1]
D0463		Dextran (high molecular weight)	C18H32O16	4125253	Major		Inter Info	[1]
D0464		Dextran (low molecular weight)	C18H32O16	4125253	Major		Inter Info	[1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [2], [7], [3], [4], [8]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[5], [6], [2], [7], [3], [4], [8]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[12]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[1]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[1]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[1]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[13]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[2], [3], [4]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[14]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1]
D1613		Tositumomab	NA	NA	Major		Inter Info	[15], [16]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[15], [16]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[1]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1]
D1395		Reteplase	NA	NA	Major		Inter Info	[1]
D1669		Urokinase	NA	NA	Major		Inter Info	[1]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[25], [26], [27]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[19], [20], [24]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[31], [61], [62]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[25], [26], [27]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[25], [26], [27]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[25], [26], [27]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[67]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[68], [69], [70]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[25], [26], [27]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[25], [26], [27]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[68], [69], [70]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[9], [74]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[75], [76]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[19], [20], [24]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[19], [20], [24]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[77], [78], [79]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[31], [61], [62]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[25], [26], [27]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[77], [80], [68], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [78], [93], [94], [79], [95]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0253		Capsicum	NA	NA	Minor		Inter Info	[96]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[96], [97], [98]

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