Details of Drug

Drug General Information (ID: D0527)
Drug Name	Doxercalciferol
Drug Type	Small molecule
Drug Synonymous	Doxcercalciferol; Hectorol; Doxercalciferol [INN]; TSA 840; BCI-101; Doxercalciferol (INN); Hectorol (TN); (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1alpha,3beta-diol; 1-Hydroxyergocalciferol; 1-alpha-Hydroxyvitamin D2; 1alpha-Hydroxyergocalciferol; 1alpha-OH-D2; 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5Z,7E,22E) Click to Show/Hide
Disease Class	GB61: Chronic kidney disease
Therapeutic Class	Vitamins
Structure
Structure	3D Structure		2D Structure
Formula	C28H44O2
InChI	1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChIKey	HKXBNHCUPKIYDM-CGMHZMFXSA-N
Canonical SMILES	CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
External Link
	Pubchem ID	5281107
	CAS Number	54573-75-0
	CHEBI ID	4712
	TTD ID	D0G5CF
	INTEDE ID	DR1757

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM008 Altered Fat-soluble drugs absorption BM009 Altered absorption (Unspecific) BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM059 Increased risk of hypermagnesemia BM107 Attenuated pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Doxercalciferol
Affected gastrointestinal absorption
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0850		Iron sucrose	C12H29Fe5Na2O23	91663255	Moderate		Inter Info	[22]
	Altered Fat-soluble drugs absorption					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[13], [1], [14], [15], [7], [16]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[13], [1], [14], [15], [7], [16]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[13], [1], [14], [15], [7], [16]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[27]
D1462		Sevelamer	C6H12ClNO	3085017	Moderate		Inter Info	[13], [1], [14], [15], [7], [16]
D1187		Orlistat	C29H53NO5	3034010	Minor		Inter Info	[34]
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Major		Inter Info	[1], [4]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Major		Inter Info	[1], [4]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[18]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[19]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[21]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[23], [24], [25]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[29]
	CYP450 enzyme induction					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[2], [3], [7], [4]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[2], [3], [7], [4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[2], [3], [7], [4]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[2], [3], [7], [4]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[13], [20]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[28]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[13], [1], [30]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[13], [1], [31], [30]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[2], [3], [7], [4]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[2], [3], [7], [4]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[2], [3], [7], [4]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[2], [7], [4]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[13], [1], [32], [33]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[2], [3], [7], [4]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[2], [3], [7], [4]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[2], [3], [7], [4]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[2], [3], [7], [4]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[2], [3], [7], [4]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[2], [3], [7], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[2], [7], [4]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[2], [3], [7], [4]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[2], [3], [7], [4]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[13], [1], [30]
Pharmacodynamic additive effects
	Increased risk of hypermagnesemia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[2], [3], [7], [4]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[2], [3], [7], [4]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[2], [3], [7], [4]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[2], [3], [7], [4]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[2], [3], [7], [4]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[2], [3], [7], [4]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[2], [3], [7], [4]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[2], [3], [7], [4]
	Increased risk of hypercalcemia					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0233		Calcifediol	C27H44O2	5283731	Major		Inter Info	[1], [2], [3]
D0234		Calcitriol	C27H44O3	5280453	Major		Inter Info	[1], [2], [3]
D0328		Cholecalciferol	C27H44O	5280795	Major		Inter Info	[1], [2], [3]
D0495		Dihydrotachysterol	C28H46O	5311071	Major		Inter Info	[1], [2], [3]
D0591		Ergocalciferol	C28H44O	5280793	Major		Inter Info	[1], [2], [3]
D1226		Paricalcitol	C27H44O3	5281104	Major		Inter Info	[1], [2], [3]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[8], [9], [10]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[8], [9], [10]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[11], [12]
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[11], [12]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[8], [9], [10]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[8], [9], [10]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[8], [9], [10]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[8], [9], [10]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[8], [9], [10]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[8], [9], [10]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[8], [9], [10]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[8], [9], [10]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0221		Burosumab	NA	NA	Major		Inter Info	[5]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[1], [4], [17]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[1], [4], [17]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[6]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA.
3	Product Information. One-Alpha (alfacalcidol). Pharmel Inc, Montreal, IN.
4	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
5	Product Information. Crysvita (burosumab). Ultragenyx Pharmaceutical, Novato, CA.
6	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
7	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
8	Santos F, Smith MJ, Chan JC "Hypercalciuria associated with long-term administration of calcitriol (1,25-dihydroxyvitamin D3). Action of hydrochlorothiazide." Am J Dis Child 140 (1986): 139-42
9	Drinka PJ, Nolten WE "Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics." J Am Geriatr Soc 32 (1984): 405-7
10	Duarte CG, Winnacker JL, Becker KL, Pace A "Thiazide-induced hypercalcemia." N Engl J Med 284 (1971): 828-30
11	Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
12	Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.
13	Cerner Multum, Inc. "Australian Product Information.".
14	Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21. [PMID: 20921291]
15	Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
16	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
17	Therapeutic Research Faculty "Natural Medicines Comprehensive Database."
18	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
19	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
20	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
21	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
22	Product Information. Velphoro (sucroferric oxyhydroxide). Fresenius Medical Care North America, Lexington, MA.
23	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
24	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
25	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
26	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
27	Product Information. Hectorol (doxercalciferol) Genzyme Corporation, Cambridge, MA.
28	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
29	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
30	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
31	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
32	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
33	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
34	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.

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