Drug General Information (ID: DDIIDLC4OP)
Drug Name			Doxercalciferol		Drug Info		Magnesium gluconate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Minerals And Electrolytes
Structure

Mechanism of Doxercalciferol-Magnesium gluconate Interaction (Severity Level: Moderate)
Increased risk of hypermagnesemia Click to Show/Hide Mechanism Graph
Drug Name		Doxercalciferol				Magnesium gluconate
Mechanism		Hypermagnesemia				Hypermagnesemia
Key Mechanism Factor 1
		Factor Name		Hypermagnesemia
		Factor Description		Hypomagnesemia is a condition that occurs when you have too much magnesium in your body. Symptoms of hypomagnesemia include: nausea, vomiting, neurological damage, abnormally low blood pressure (hypotension), flushing, and headaches.
Mechanism Description		Increased risk of hypermagnesemia by the combination of Doxercalciferol and Magnesium gluconate

Recommended Action
Management		Patients on chronic renal dialysis treated with a vitamin D analog should avoid magnesium-containing products.

References
1	Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA.
2	Product Information. One-Alpha (alfacalcidol). Pharmel Inc, Montreal, IN.
3	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
4	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.