Details of Drug

Drug General Information (ID: D0460)
Drug Name	Dexmethylphenidate
Drug Type	Small molecule
Drug Synonymous	Dexmethylphenidate; d-threo-Methylphenidate; (+)-threo-Methylphenidate; Focalin; UNII-M32RH9MFGP; d-Methylphenidate; 40431-64-9; D-TMP; Dexmethylphenidate [INN]; M32RH9MFGP; CHEMBL827; CHEBI:51860; methyl (R)-phenyl[(R)-piperidin-2-yl]acetate; methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate; Focalin XR; Dexmethylphenidate (INN); methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate; Methyl D-phenidate; Dex methylphenidate; D-MPH; threo-(+)-Methylphenidate; Attenade; dexmetilfenidato; dexmethylphenidatum; dex-methylphenidate; d-threo methylphenidate; Methylphenidate d-threo-form; SCHEMBL34326; GTPL7554; DTXSID70893769; ZINC896711; 40572-71-2; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, (alphaR,2R)-; BDBM50062915; PDSP1_000871; PDSP1_000903; PDSP2_000857; PDSP2_000889; DB06701; D07806; Q1207210; UNII-207ZZ9QZ49 component DUGOZIWVEXMGBE-CHWSQXEVSA-N; 2-Piperidineacetic acid, .alpha.-phenyl-, methyl ester, (.alpha.S,2S)- Click to Show/Hide
Therapeutic Class	Norepinephrine-Dopamine Reuptake Inhibitor
Structure
Structure	3D Structure		2D Structure
Formula	C14H19NO2
InChI	InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1
InChIKey	DUGOZIWVEXMGBE-CHWSQXEVSA-N
Canonical SMILES	COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2
External Link
	Pubchem ID	154101
	INTEDE ID	DR1760
	VARIDT ID	DR00844

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM025 Decreased metabolism (Unspecific) BM041 Additive hypertensive effects BM061 Increased risk of hyperpyrexia BM069 Increased risk of lowers seizure threshold BM089 Antagonize the effect of antihypertensive agents BM093 Antagonize the effect of dopaminergic agents
Relation Graph

Full list of drugs interacting with Dexmethylphenidate
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[147], [148], [149], [150], [39], [40]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[147], [148], [149], [150], [39], [40]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[147], [148], [149], [150], [39], [40]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[147], [148], [149], [150], [39], [40]
	Decreased metabolism (Unspecific)					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[122], [123], [124], [125], [126], [39], [127], [128]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[122], [123], [124], [125], [126], [39], [127], [128]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[122], [123], [124], [125], [126], [39], [127], [128]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[122], [123], [124], [125], [126], [39], [127], [128]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[122], [123], [124], [125], [126], [39], [127], [128]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[40]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[122], [123], [124], [125], [126], [39], [127], [128]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[16], [17], [18]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[16], [17], [18]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[19], [20]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[26], [48], [27], [16], [50], [28], [29], [51], [31], [32], [52], [33], [53], [54], [34], [59], [35], [60], [80], [42], [81], [43], [45], [82], [46], [47]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[39], [41], [95]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[39], [41], [95]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[39], [41], [95]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[39], [41], [95]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[39], [41], [95]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[39], [41], [95]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[39], [41], [95]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[39], [41], [95]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[39], [41], [95]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[39], [41], [95]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[39], [41], [95]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[39], [41], [95]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[39], [41], [95]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[39], [41], [95]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[39], [41], [95]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[39], [41], [95]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[39], [41], [95]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[16], [146]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[39], [41], [95]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[39], [41], [95]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[39], [41], [95]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[39], [41], [95]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[39], [41], [95]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[39], [41], [95]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[26], [48], [27], [16], [50], [28], [29], [51], [31], [32], [52], [33], [53], [54], [34], [59], [35], [60], [80], [42], [43], [45], [82], [46], [47]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[39], [41], [95]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[39], [41], [95]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[39], [41], [95]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[39], [41], [95]
	Increased risk of hyperpyrexia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[26], [48], [27], [19], [16], [49], [50], [28], [29], [51], [30], [31], [32], [52], [33], [53], [54], [55], [56], [57], [34], [58], [59], [35], [60], [61], [62], [63], [36], [37], [64], [65], [38], [39], [66], [67], [68], [40], [69], [70], [41], [71], [42], [72], [43], [44], [73], [74], [45], [46], [75], [76], [77], [47]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
	Increased risk of lowers seizure threshold					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[21], [22], [23], [24], [25]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[21], [22], [23], [24], [25]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[83], [14], [13], [84]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[132], [16], [133]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[132], [16], [133]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[132], [133], [16]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[134], [135], [136], [137], [138], [139], [140], [141]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[143], [144], [145]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[19], [16], [87]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[129], [130], [131]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[19], [16], [87]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[19], [16], [87]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[129], [130], [131]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[129], [130], [131]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[19], [16], [87]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[19], [16], [87]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[19], [16], [87]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[129], [130], [131]
	Antagonize the effect of dopaminergic agents					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[78], [79]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[85], [35], [86]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[96], [97], [142], [98], [100], [101], [102], [103], [104], [85], [105], [106], [107], [108], [109], [110], [37], [42], [86], [118], [119], [120], [121]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [85], [105], [106], [35], [107], [108], [109], [110], [37], [111], [112], [38], [113], [114], [39], [115], [40], [116], [117], [42], [86], [118], [119], [120], [121]

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37	Product Information. Adderall (amphetamine-dextroamphetamine) Shire Richwood Pharmaceutical Company, Florence, KY.
38	Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
39	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
40	Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
41	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
42	Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
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64	Product Information. Aldomet (methyldopa). Merck & Co, Inc, West Point, PA.
65	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
66	Product Information. Iopidine (apraclonidine). Alcon Laboratories Inc, Fort Worth, TX.
67	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
68	Product Information. Parcopa (carbidopa-levodopa). Schwarz Pharma, Mequon, WI.
69	Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
70	Product Information. Stalevo 50 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
71	Product Information. Tyzine (tetrahydrozoline). Kenwood Laboratories, Fairfield, NJ.
72	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
73	Sharpe J, Marquez-Julio A, Ashby P "Idiopathic orthostatic hypotension treated with levodopa and MAO inhibitor: a preliminary report." Can Med Assoc J 107 (1972): 296-300. [PMID: 5056115]
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79	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
80	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
81	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
82	Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]
83	Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
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87	Product Information. Azstarys (dexmethylphenidate-serdexmethylphenidate). Corium, Inc., Grand Rapids, MI.
88	Burke MS, Josephson A, Lightsey A "Combined methylphenidate and imipramine complication." J Am Acad Child Adolesc Psychiatry 34 (1995): 403-4. [PMID: 7751253]
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111	Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.
112	Product Information. Desoxyn (methamphetamine) Abbott Pharmaceutical, Abbott Park, IL.
113	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
114	Product Information. Fastin (phentermine). SmithKline Beecham, Philadelphia, PA.
115	Product Information. Prelu-2 (phendimetrazine) Boehringer-Ingelheim, Ridgefield, CT.
116	Product Information. Sanorex (mazindol) Novartis Pharmaceuticals, East Hanover, NJ.
117	Product Information. Tenuate (diethylpropion) Aventis Pharmaceuticals, Swiftwater, PA.
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123	Ishii M, Tatsuzawa Y, Yoshino A, Nomura S "Serotonin syndrome induced by augmentation of SSRI with methylphenidate." Psychiatry Clin Neurosci 62 (2008): 246. [PMID: 18412855]
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126	Product Information. Concerta (methylphenidate). Alza, Palo Alto, CA.
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132	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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139	Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
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145	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
146	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
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