Drug General Information (ID: DDISBTWO8P)
Drug Name			Polythiazide		Drug Info		Dexmethylphenidate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Norepinephrine-Dopamine Reuptake Inhibitor
Structure

Mechanism of Polythiazide-Dexmethylphenidate Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Polythiazide				Dexmethylphenidate
Mechanism		Antihypertensive agent				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Polythiazide when combined with Dexmethylphenidate

Recommended Action
Management		Caution and monitoring of blood pressure is recommended if methylphenidate, dexmethylphenidate or serdexmethylphenidate are administered with antihypertensives agents such as: potassium-sparing and thiazide diuretics, calcium channel blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers or centrally acting alpha-2 receptor agonists. The dosage of the antihypertensive drug should be adjusted as needed.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Azstarys (dexmethylphenidate-serdexmethylphenidate). Corium, Inc., Grand Rapids, MI.