Details of Drug

Drug General Information (ID: D0455)
Drug Name	Dexamethasone (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Adexone; Anaflogistico; Aphtasolon; Aphthasolone; Auxiron; Azium; Calonat; Corson; Corsone; Cortisumman; DXM; Decacort; Decacortin; Decaderm; Decadron; Decagel; Decaject; Decalix; Decameth; Decasone; Decaspray; Dectancyl; Dekacort; Deltafluorene; Dergramin; Deronil; Desadrene; Desametasone; Desamethasone; Desameton; Deseronil; Dexacort; Dexacortal; Dexacortin; Dexadeltone; Dexafarma; Dexair; Dexalona; Dexaltin; Dexametasona; Dexameth; Dexamethansone; Dexamethasonum; Dexamethazone; Dexamonozon; Dexapolcort; Dexaprol; Dexason; Dexasone; Dexinolon; Dexinoral; Dexone; Dexonium; Dexpak; Dextelan; Dezone; Dinormon; Dxms; Fluormethylprednisolone; Fluormone; Fluorocort; Fortecortin; Gammacorten; Hexadecadrol; Hexadrol; IontoDex; Loverine; Luxazone; Maxidex; Mediamethasone; Methylfluorprednisolone; Mexidex; Millicorten; Mymethasone; Oradexon; Policort; Posurdex; Prodex; Spoloven; Superprednol; Turbinaire; Visumetazone; Alcon Brand of Dexamethasone; Bisu DS; Desametasone [DCIT]; Dexa Mamallet; Dexamethasone Base; Dexamethasone Intensol; Dexamethasone alcohol; ECR Brand of Dexamethasone; Foy Brand of Dexamethasone; Hexadrol Elixir; Hexadrol Tablets; ICN Brand of Dexamethasone; Lokalison F; Merck Brand of Dexamethasone; Pet Derm III; Prednisolon F; Prednisolone F; Sunia Sol D; Dexone 4; MK 125; Merz Brand 1 of Dexamethasone; Merz Brand 2 of Dexamethasone; Aeroseb-D; Aeroseb-Dex; Azium (Veterinary); Decadron (TN); Decadron Tablets, Elixir; Decadron, Dexamethasone; Decadron-LA; Dex-ide; Dexa-Cortidelt;Dexa-Cortisyl; Dexa-Mamallet; Dexa-Scheroson; Dexa-sine; Dexacen-4; Dexametasona [INN-Spanish]; Dexamethasonum [INN-Latin]; Dexone 0.5; Dexone 0.75; Dexone 1.5; Hl-dex; Isopto-Dex; OTO-104; Ocu-trol;Pet-Derm Iii; SK-Dexamethasone; Decaject L.A.; Dexamethasone [INN:BAN:JAN]; Decaject-L.A.; Dexamethasone (JP15/USP/INN); Delta1-9alpha-Fluoro-16alpha-methylcortisol; Delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol; (3H)-Dexamethasone; 1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol; 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoroprednisolone; 16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol; 16.alpha.-Methyl-9.alpha.-fluoroprednisolone; 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol; 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone; 16alpha-Methyl-9alpha-fluoroprednisolone; 9-alpha-Fluoro-16-alpha-methylprednisolone; 9.alpha.-Fluoro-16.alpha.-methylprednisolone; 9A-FLUORO-16BETA-METHYLPREDNISOLONE; 9alpha-Fluoro-16alpha-methylprednisolone Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H29FO5
InChI	1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey	UREBDLICKHMUKA-CXSFZGCWSA-N
Canonical SMILES	CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
External Link
	Pubchem ID	5743
	CAS Number	18296
	CHEBI ID	41879
	TTD ID	D0IT2G
	VARIDT ID	DR00215

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Dexamethasone (ophthalmic)
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[4], [5], [6]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[4], [5], [6]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[4], [5], [6]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[4], [5], [6]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[4], [5], [6]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[4], [5], [6]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[4], [5], [6]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[4], [5], [6]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[4], [5], [6]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[4], [5], [6]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[4], [5], [6]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[4], [5], [6]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[4], [5], [6]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[4], [5], [6]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[4], [5], [6]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[4], [5], [6]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[4], [5], [6]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[4], [5], [6]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[4], [5], [6]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[4], [5], [6]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[4], [5], [6]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[4], [5], [6]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[4], [5], [6]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[4], [5], [6]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[4], [5], [6]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[4], [5], [6]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[4], [5], [6]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[4], [5], [6]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[4], [5], [6]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[7], [8], [9]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[7], [8], [9]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[7], [8], [9]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[7], [8], [9]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[7], [8], [9]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[7], [8], [9]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Minor		Inter Info	[10], [11], [12]
D0013		Acetohexamide	C15H20N2O4S	1989	Minor		Inter Info	[10], [11], [12]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Minor		Inter Info	[10], [11], [12]
D0029		Albiglutide	C148H224N40O45	145994868	Minor		Inter Info	[10], [11], [12]
D0042		Alogliptin	C18H21N5O2	11450633	Minor		Inter Info	[10], [11], [12]
D0245		Canagliflozin	C24H25FO5S	24812758	Minor		Inter Info	[10], [11], [12]
D0418		Dapagliflozin	C21H25ClO6	9887712	Minor		Inter Info	[10], [11], [12]
D0565		Empagliflozin	C23H27ClO7	11949646	Minor		Inter Info	[10], [11], [12]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Minor		Inter Info	[10], [11], [12]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Minor		Inter Info	[10], [11], [12]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Minor		Inter Info	[10], [11], [12]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Minor		Inter Info	[10], [11], [12]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Minor		Inter Info	[10], [11], [12]
D0930		Linagliptin	C25H28N8O2	10096344	Minor		Inter Info	[10], [11], [12]
D0936		Liraglutide	C172H265N43O51	16134956	Minor		Inter Info	[10], [11], [12]
D0941		Lixisenatide	C215H347N61O65S	90472060	Minor		Inter Info	[10], [11], [12]
D1326		Pramlintide	C171H267N51O53S2	70691388	Minor		Inter Info	[10], [11], [12]
D1449		Saxagliptin	C18H25N3O2	11243969	Minor		Inter Info	[10], [11], [12]
D1477		Sitagliptin	C16H15F6N5O	4369359	Minor		Inter Info	[10], [11], [12]
D0727		Glimepiride	C24H34N4O5S	3476	Minor		Inter Info	[10], [11], [12]
D0728		Glipizide	C21H27N5O4S	3478	Minor		Inter Info	[10], [11], [12]
D0730		Glyburide	C23H28ClN3O5S	3488	Minor		Inter Info	[10], [11], [12]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Minor		Inter Info	[10], [11], [12]
D0813		Insulin human	C257H383N65O77S6	118984375	Minor		Inter Info	[10], [11], [12]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Minor		Inter Info	[10], [11], [12]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Minor		Inter Info	[10], [11], [12]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Minor		Inter Info	[10], [11], [12]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Minor		Inter Info	[10], [11], [12]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Minor		Inter Info	[10], [11], [12]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Minor		Inter Info	[10], [11], [12]
D1015		Metformin	C4H11N5	4091	Minor		Inter Info	[10], [11], [12]
D1064		Miglitol	C8H17NO5	441314	Minor		Inter Info	[10], [11], [12]
D1112		Nateglinide	C19H27NO3	5311309	Minor		Inter Info	[10], [11], [12]
D1294		Pioglitazone	C19H20N2O3S	4829	Minor		Inter Info	[10], [11], [12]
D1392		Repaglinide	C27H36N2O4	65981	Minor		Inter Info	[10], [11], [12]
D1429		Rosiglitazone	C18H19N3O3S	77999	Minor		Inter Info	[10], [11], [12]
D1601		Tolazamide	C14H21N3O3S	5503	Minor		Inter Info	[10], [11], [12]
D1603		Tolbutamide	C12H18N2O3S	5505	Minor		Inter Info	[10], [11], [12]
D1652		Troglitazone	C24H27NO5S	5591	Minor		Inter Info	[10], [11], [12]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Minor		Inter Info	[10], [11], [12]
D1782		Ertugliflozin	C22H25ClO7	44814423	Minor		Inter Info	[10], [11], [12]
D1784		Exenatide	C184H282N50O60S	45588096	Minor		Inter Info	[10], [11], [12]
D1887		Semaglutide	C187H291N45O59	56843331	Minor		Inter Info	[10], [11], [12]
	Antagonize the effect of vaccine/toxoid					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[1], [2], [3]

References
1	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
2	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	CDC. Centers for Disease Control and Prevention "Clinical guidance for smallpox vaccine use in a postevent vaccination program.".
4	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
5	Finkenbine RD, Frye MD "Case of psychosis due to prednisone-clarithromycin interaction." Gen Hosp Psychiat 20 (1998): 325-6. [PMID: 9788033]
6	Soldatos G, Sztal-Mazer S, Woolley I, Stockigt J "Exogenous glucocorticoid excess as a result of ritonavir-fluticasone interaction." Intern Med J 35 (2005): 67-8. [PMID: 15667475]
7	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
8	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
9	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
10	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11	Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
12	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]

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