Drug General Information (ID: DDIO0AS1PX)
Drug Name			Dexamethasone (ophthalmic)		Drug Info		Semaglutide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antidiabetic Agents
Structure

Mechanism of Dexamethasone (ophthalmic)-Semaglutide Interaction (Severity Level: Minor)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Dexamethasone (ophthalmic)				Semaglutide
Mechanism 1		Hyperglycemia				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Semaglutide when combined with Dexamethasone (ophthalmic)
Mechanism 2		Hyperglycemic effects				Antidiabetic agent
Key Mechanism Factor 2
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Semaglutide when combined with Dexamethasone (ophthalmic)

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
3	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]