Drug General Information (ID: D0444)
  Drug Name
Deserpidine
  Drug Type Small molecule
  Drug Synonymous
Canescin; Canescine; Deresperine; Desepridine; Deserpidin; Deserpidina; Deserpidinum; Desmethoxyreserpine; Halmonyl; Harmonyl; Raunormin; Raunormine; Recanescin; Recanescine; Reserpidine; Tranquinil; Lilly 22641; ORETICYL 50; A-11025; Deserpidina [INN-Spanish]; Deserpidine (INN); Deserpidine [INN:BAN]; Deserpidinum [INN-Latin]; Halmonyl (TN); MD-0232; Deserpidic acid, methyl ester, 3,4,5-trimethoxybenzoate; Methyl 17alpha-methoxy-18beta-(3,4,5-trimethoxybenzoyloxy)-3beta,20alpha-yohimban-16beta-carboxylat; Methyl 17alpha-methoxy-18beta-((3,4,5-trimethoxybenzoyl)oxy)-3beta,20alpha-yohimban-16beta-carboxylate; Methyl 18beta-hydroxy-17alpha-methoxy-3beta,20alpha-yohimban-16beta-carboxylate, 3,4,5-trimethoxybenzoate (ester); Methyl (3beta,16beta,17alpha,18beta,20alpha)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate; Methyl (3beta,16beta,17alpha,18beta,20alpha)-17-(methyloxy)-18-({[3,4,5-tris(methyloxy)phenyl]carbonyl}oxy)yohimban-16-carboxylate; Benz[g]indolo[2,3-a]quinolizine-1-carboxylic acid, 1,2,3,4,4a,5,7,8,-13,13b,14,14a-dodecahydro-3-hydroxy-2-methoxy-, methyl ester, 3,4,5-trimethoxybenzoate; (3beta,16beta,17alpha,18beta,20alpha)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester; 11-Demethoxyreserpine; 11-Desmethoxyreserpine; 17.alpha.-Methoxy-18.beta.-[(3,4,5-trimethoxybenzoyl)oxy]-3.beta.,20.alpha.-yohimban-16.beta.-carboxylic acid methyl ester; 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-17-alpha-methoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester); 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-17-alpha-methoxy-,methyl ester, 3,4,5-trimethoxybenzoate (ester)
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  Disease Class BA00-BA04: Hypertension
  Therapeutic Class Antihypertensive Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C32H38N2O8
  InChI 1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1
  InChIKey CVBMAZKKCSYWQR-WCGOZPBSSA-N
  Canonical SMILES COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=CC=CC=C45)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
  External Link
Pubchem ID 8550
CAS Number 131-01-1
CHEBI ID 27478
TTD ID D09HDR

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM014  Interference of cell/tissue uptake
BM041  Additive hypertensive effects
BM042  Additive hypotensive effects
BM049  Increased risk of atrioventricular block
BM064  Increased risk of hypoglycemia
BM083  Potentiated the pharmacological effects (Unspecific)
BM089  Antagonize the effect of antihypertensive agents
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Deserpidine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[1]
D1821
 
Iobenguane (I-123)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[47], [48], [49]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  8
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[50], [51], [52], [53], [54]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[52], [53], [54]
   Additive hypotensive effects Drug Num:  119
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[2]
D0030
 
Aldesleukin
 
NA
 
NA
Moderate    Inter Info   
[3]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[4], [5], [6]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[4], [5], [6]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[4], [5], [6]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[10], [11], [12]
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[13], [14], [15]
D0143
 
Baclofen
 
C10H12ClNO2
 
2284 
Moderate    Inter Info   
[4], [5], [6]
D0158
 
Bendroflumethiazide
 
C15H14F3N3O4S2
 
2315 
Moderate    Inter Info   
[16], [17], [18]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[13], [14], [15]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[13], [14], [15]
D0222
 
Buspirone
 
C21H31N5O2
 
2477 
Moderate    Inter Info   
[4], [5], [6]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[4], [5], [6]
D0263
 
Carisoprodol
 
C12H24N2O4
 
2576 
Moderate    Inter Info   
[4], [5], [6]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[4], [5], [6]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[16], [17], [18]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[16], [17], [18]
D0327
 
Chlorzoxazone
 
C7H4ClNO2
 
2733 
Moderate    Inter Info   
[4], [5], [6]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[4], [5], [6]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[4], [5], [6]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[4], [5], [6]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0055
 
Amifostine
 
C5H15N2O3PS
 
2141 
Moderate    Inter Info   
[10], [18], [34]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0128
 
Avanafil
 
C23H26ClN7O3
 
9869929 
Moderate    Inter Info   
[35], [36], [37]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[4], [5], [6]
D0202
 
Brexpiprazole
 
C25H27N3O2S
 
11978813 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Moderate    Inter Info   
[4], [5], [6]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[40], [38], [41]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[4], [5], [6]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[40], [38], [41]
D0445
 
Desflurane
 
C3H2F6O
 
42113 
Moderate    Inter Info   
[42], [43]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[4], [5], [6]
D0475
 
Dichloralphenazone
 
C15H18Cl6N2O5
 
10188 
Moderate    Inter Info   
[4], [5], [6]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[4], [5], [6]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[4], [5], [6]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[40], [38], [41]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[38], [45], [46]
D0751
 
Halothane
 
C2HBrClF3
 
3562 
Moderate    Inter Info   
[42], [43]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[42], [43]
D0918
 
Levodopa
 
C9H11NO4
 
6047 
Moderate    Inter Info   
[10], [11], [55]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[38], [61], [62]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[63]
D1006
 
Mepyramine
 
C17H23N3O
 
4992 
Moderate    Inter Info   
[4], [5], [6]
D1084
 
Molindone
 
C16H24N2O2
 
23897 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[48], [64], [62]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[17], [18], [65]
D1148
 
Nitrous acid
 
HNO2
 
24529 
Moderate    Inter Info   
[66], [67], [68]
D1149
 
Nitrous oxide
 
N2O
 
948 
Moderate    Inter Info   
[42], [43]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[4], [5], [6]
D1188
 
Orphenadrine
 
C18H23NO
 
4601 
Moderate    Inter Info   
[4], [5], [6]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[16], [17], [18]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[4], [5], [6]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Moderate    Inter Info   
[4], [5], [6]
D1408
 
Riociguat
 
C20H19FN8O2
 
11304743 
Moderate    Inter Info   
[69]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[38], [45], [46]
D1485
 
Sodium oxybate
 
C4H7NaO3
 
23663870 
Moderate    Inter Info   
[4], [5], [6]
D1576
 
Thiothixene
 
C23H29N3O2S2
 
941651 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0459
 
Dexmedetomidine
 
C13H16N2
 
5311068 
Moderate    Inter Info   
[40], [70], [71]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[4], [5], [6]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[4], [5], [6]
D0533
 
Dronabinol
 
C21H30O2
 
16078 
Moderate    Inter Info   
[4], [5], [6]
D0570
 
Enflurane
 
C3H2ClF5O
 
3226 
Moderate    Inter Info   
[42], [43]
D0625
 
Etomidate
 
C14H16N2O2
 
667484 
Moderate    Inter Info   
[42], [43]
D0644
 
Fenoldopam
 
C16H16ClNO3
 
3341 
Moderate    Inter Info   
[18], [72]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[4], [5], [6]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[16], [17], [18]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[4], [5], [6]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[16], [17], [18]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[4], [5], [6]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[38], [45], [46]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[4], [5], [6]
D0855
 
Isoflurane
 
C3H2ClF5O
 
3763 
Moderate    Inter Info   
[42], [43]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[4], [5], [6]
D0957
 
Loxapine
 
C18H18ClN3O
 
3964 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[4], [5], [6]
D1005
 
Meprobamate
 
C9H18N2O4
 
4064 
Moderate    Inter Info   
[4], [5], [6]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[23], [25], [27]
D1014
 
Metaxalone
 
C12H15NO3
 
15459 
Moderate    Inter Info   
[4], [5], [6]
D1023
 
Methocarbamol
 
C11H15NO5
 
4107 
Moderate    Inter Info   
[4], [5], [6]
D1030
 
Methoxyflurane
 
C3H4Cl2F2O
 
4116 
Moderate    Inter Info   
[42], [43]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[16], [17], [18]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[4], [5], [6]
D1848
 
Minoxidil (topical)
 
C9H15N5O
 
4201 
Moderate    Inter Info   
[73], [74]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Moderate    Inter Info   
[4], [5], [6]
D1096
 
Nabilone
 
C24H36O3
 
5284592 
Moderate    Inter Info   
[4], [5], [6]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[4], [5], [6]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[4], [5], [6]
D1251
 
Pentoxifylline
 
C13H18N4O3
 
4740 
Moderate    Inter Info   
[75]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1356
 
Propofol
 
C12H18O
 
4943 
Moderate    Inter Info   
[42], [43]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[4], [5], [6]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1465
 
Sildenafil
 
C22H30N6O4S
 
135398744 
Moderate    Inter Info   
[35], [36], [37]
D1573
 
Thiopental
 
C11H18N2O2S
 
3000715 
Moderate    Inter Info   
[42], [43]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[38], [45], [46]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[4], [5], [6]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[35], [36], [37]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[76], [77], [78]
D1716
 
Zaleplon
 
C17H15N5O
 
5719 
Moderate    Inter Info   
[4], [5], [6]
D1729
 
Zolpidem
 
C19H21N3O
 
5732 
Moderate    Inter Info   
[4], [5], [6]
D0711
 
Garlic
 
NA
 
NA
Minor    Inter Info   
[80], [81]
D1527
 
Tadalafil
 
C22H19N3O4
 
110635 
Minor    Inter Info   
[82], [83]
   Increased risk of atrioventricular block Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0363
 
Clonidine
 
C9H9Cl2N3
 
2803 
Moderate    Inter Info   
[33]
   Increased risk of hypoglycemia Drug Num:  17
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[30], [31], [32]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[30], [31], [32]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[30], [31], [32]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[30], [31], [32]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[30], [31], [32]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[30], [31], [32]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[30], [31], [32]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[30], [31], [32]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[30], [31], [32]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[30], [31], [32]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[30], [31], [32]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[30], [31], [32]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[30], [31], [32]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[30], [31], [32]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[30], [31], [32]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[30], [31], [32]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[30], [31], [32]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  13
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0921
 
Levonordefrin
 
C9H13NO3
 
164739 
Moderate    Inter Info   
[56], [57], [44]
D1108
 
Naphazoline (ophthalmic)
 
C14H14N2
 
4436 
Moderate    Inter Info   
[56], [57], [44]
D1567
 
Tetryzoline (nasal)
 
C13H16N2
 
5419 
Moderate    Inter Info   
[56], [57], [44]
D1568
 
Tetryzoline (ophthalmic)
 
C13H16N2
 
5419 
Moderate    Inter Info   
[56], [57], [44]
D0510
 
Dobutamine
 
C18H23NO3
 
36811 
Moderate    Inter Info   
[56], [57], [44]
D0581
 
Epinephrine
 
C9H13NO3
 
5816 
Moderate    Inter Info   
[56], [57], [44]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[56], [57], [44]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Moderate    Inter Info   
[56], [57], [44]
D1153
 
Norepinephrine
 
C8H11NO3
 
439260 
Moderate    Inter Info   
[56], [57], [44]
D1204
 
Oxymetazoline (nasal)
 
C16H24N2O
 
4636 
Moderate    Inter Info   
[56], [57], [44]
D1205
 
Oxymetazoline (ophthalmic)
 
C16H24N2O
 
4636 
Moderate    Inter Info   
[56], [57], [44]
D1206
 
Oxymetazoline (topical)
 
C16H24N2O
 
4636 
Moderate    Inter Info   
[56], [57], [44]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[56], [57], [44]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  30
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0074
 
Amphetamine
 
C9H13N
 
3007 
Moderate    Inter Info   
[7], [8], [9]
D0165
 
Benzphetamine
 
C17H21N
 
5311017 
Moderate    Inter Info   
[7], [8], [9]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Moderate    Inter Info   
[38], [39]
D0392
 
Corticotropin
 
C207H308N56O58S
 
16132265 
Moderate    Inter Info   
[38], [39]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Moderate    Inter Info   
[38], [39]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[38], [39]
D0460
 
Dexmethylphenidate
 
C14H19NO2
 
154101 
Moderate    Inter Info   
[7], [8], [9]
D0465
 
Dextroamphetamine
 
C9H13N
 
5826 
Moderate    Inter Info   
[7], [8], [9]
D0579
 
Ephedrine
 
C10H15NO
 
9294 
Moderate    Inter Info   
[7], [42], [44]
D0857
 
Isometheptene
 
C9H19N
 
22297 
Moderate    Inter Info   
[7], [42], [44]
D0926
 
Licorice
 
C42H62O16Zn
 
163463 
Moderate    Inter Info   
[58], [59], [60]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[7], [8], [9]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Moderate    Inter Info   
[7], [8], [9]
D1262
 
Phendimetrazine
 
C12H17NO
 
30487 
Moderate    Inter Info   
[7], [8], [9]
D1563
 
Tetracosactide
 
C136H210N40O31S
 
16133802 
Moderate    Inter Info   
[38], [39]
D0486
 
Diethylpropion
 
C13H19NO
 
7029 
Moderate    Inter Info   
[7], [8], [9]
D0517
 
Dopamine
 
C8H11NO2
 
681 
Moderate    Inter Info   
[7], [42], [44]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Moderate    Inter Info   
[38], [39]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Moderate    Inter Info   
[38], [39]
D1039
 
Methylphenidate
 
C14H19NO2
 
4158 
Moderate    Inter Info   
[7], [8], [9]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Moderate    Inter Info   
[38], [39]
D1270
 
Phentermine
 
C10H15N
 
4771 
Moderate    Inter Info   
[7], [8], [9]
D1276
 
Phenylephrine
 
C9H13NO2
 
6041 
Moderate    Inter Info   
[7], [42], [44]
D1277
 
Phenylephrine (nasal)
 
C9H13NO2
 
6041 
Moderate    Inter Info   
[7], [42], [44]
D1278
 
Phenylephrine (ophthalmic)
 
C9H13NO2
 
6041 
Moderate    Inter Info   
[7], [42], [44]
D1281
 
Phenylpropanolamine
 
C9H13NO
 
26934 
Moderate    Inter Info   
[7], [42], [44]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Moderate    Inter Info   
[38], [39]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Moderate    Inter Info   
[38], [39]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Moderate    Inter Info   
[7], [42], [44]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[38], [39]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[79], [18]
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