Details of Drug

Drug General Information (ID: D0417)
Drug Name	Dantrolene
Drug Type	Small molecule
Drug Synonymous	Dantrium; Dantroleno; Dantrolenum; DANTROLENE SODIUM; Dantrium Intravenous; Dantrium (TN); Dantrolen (TN); Dantroleno [INN-Spanish]; Dantrolenum [INN-Latin]; F-368; Dantrolene (USAN/INN); Dantrolene [USAN:BAN:INN]; 1-(((5-(4-Nitrophenyl)-2-furanyl)methylene)amino)-2,4-imidazolidinedione; 1-((5-(p-Nitrophenyl)furfurylidene)amino)hydantoin; 1-({(1E)-[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione; 1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione; 1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione Click to Show/Hide
Disease Class	MG26: Fever
Therapeutic Class	Muscle Relaxants
Structure
Structure	3D Structure		2D Structure
Formula	C14H10N4O5
InChI	1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+
InChIKey	OZOMQRBLCMDCEG-VIZOYTHASA-N
Canonical SMILES	C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]
External Link
	Pubchem ID	6914273
	CAS Number	7261-97-4
	TTD ID	D0I8DD

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM045 Additive neuromuscular blocking effects BM055 Increased risk of hepatotoxicity BM058 Increased risk of hyperkalemia
Relation Graph

Full list of drugs interacting with Dantrolene
Affected intra/extra-hepatic metabolism
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 211
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [1], [10], [11], [12], [13], [14], [15], [16]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[20]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[20]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[20]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[24], [25]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[29], [30], [31]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[1]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[20]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[32], [33], [34]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[32], [33], [34]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[32], [33], [34]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[38], [39]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[40], [37], [41]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[32], [33], [34]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[32], [33], [34]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[32], [33], [34]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[32], [33], [34]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[40], [37], [41]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[40], [37], [41]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[32], [33], [34]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[32], [33], [34]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[32], [33], [34]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[32], [33], [34]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[32], [33], [34]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[32], [33], [34]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[32], [33], [34]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[32], [33], [34]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[32], [33], [34]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[32], [33], [34]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[32], [33], [34]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[32], [33], [34]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[32], [33], [34]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[32], [33], [34]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[32], [33], [34]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[32], [33], [34]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[32], [33], [34]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[32], [33], [34]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[32], [33], [34]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[32], [33], [34]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[32], [33], [34]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[32], [33], [34]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[32], [33], [34]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[32], [33], [34]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[59]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[32], [33], [34]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[32], [33], [34]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[32], [33], [34]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[32], [33], [34]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[32], [33], [34]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[32], [33], [34]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[32], [33], [34]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[32], [33], [34]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[32], [33], [34]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[32], [33], [34]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[35], [61]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[32], [33], [34]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[32], [33], [34]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[62]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[32], [33], [34]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[32], [33], [34]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[32], [33], [34]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[32], [33], [34]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[32], [33], [34]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[64]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[32], [33], [34]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[65], [66]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[32], [33], [34]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[32], [33], [34]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[32], [33], [34]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[32], [33], [34]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[32], [33], [34]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[32], [33], [34]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[32], [33], [34]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[32], [33], [34]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[32], [33], [34]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[32], [33], [34]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[32], [33], [34]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[32], [33], [34]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[32], [33], [34]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[32], [33], [34]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[32], [33], [34]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[32], [33], [34]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[32], [33], [34]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[32], [33], [34]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[32], [33], [34]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[32], [33], [34]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[32], [33], [34]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[32], [33], [34]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[32], [33], [34]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[32], [33], [34]
D1675		Valerian	NA	NA	Moderate		Inter Info	[32], [33], [34]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[32], [33], [34]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[32], [33], [34]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[32], [33], [34]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[32], [33], [34]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[32], [33], [34]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[32], [33], [34]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[32], [33], [34]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[32], [33], [34]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[32], [33], [34]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[32], [33], [34]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[32], [33], [34]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[32], [33], [34]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[32], [33], [34]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[32], [33], [34]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[32], [33], [34]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[79], [80], [81], [37], [82]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[32], [33], [34]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[32], [33], [34]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[32], [33], [34]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[32], [33], [34]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[32], [33], [34]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[32], [33], [34]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[32], [33], [34]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[32], [33], [34]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[32], [33], [34]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[32], [33], [34]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[32], [33], [34]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[32], [33], [34]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[83], [79], [84]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[32], [33], [34]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[32], [33], [34]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[32], [33], [34]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[32], [33], [34]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[32], [33], [34]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[32], [33], [34]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[32], [33], [34]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[32], [33], [34]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[32], [33], [34]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[32], [33], [34]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[32], [33], [34]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[32], [33], [34]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[32], [33], [34]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[32], [33], [34]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[32], [33], [34]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[32], [33], [34]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[32], [33], [34]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[32], [33], [34]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[79], [87], [82]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[32], [33], [34]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[32], [33], [34]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[32], [33], [34]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[32], [33], [34]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[32], [33], [34]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[32], [33], [34]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[32], [33], [34]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[32], [33], [34]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[32], [33], [34]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[32], [33], [34]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[32], [33], [34]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[32], [33], [34]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[32], [33], [34]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[32], [33], [34]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[32], [33], [34]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[32], [33], [34]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[32], [33], [34]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[32], [33], [34]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[32], [33], [34]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[32], [33], [34]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[32], [33], [34]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[32], [33], [34]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[32], [33], [34]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[32], [33], [34]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[32], [33], [34]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[32], [33], [34]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[32], [33], [34]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[32], [33], [34]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[32], [33], [34]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[88]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[32], [33], [34]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[32], [33], [34]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[91]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[32], [33], [34]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[32], [33], [34]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[32], [33], [34]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[32], [33], [34]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[32], [33], [34]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[32], [33], [34]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[32], [33], [34]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[32], [33], [34]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[32], [33], [34]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[32], [33], [34]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[32], [33], [34]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[32], [33], [34]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[32], [33], [34]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[32], [33], [34]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[32], [33], [34]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[32], [33], [34]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[32], [33], [34]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[32], [33], [34]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[32], [33], [34]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[32], [33], [34]
	Additive neuromuscular blocking effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0196		Botulinum toxin type A	NA	NA	Moderate		Inter Info	[53], [54], [55]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[53], [54], [55]
	Increased risk of hepatotoxicity					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Major		Inter Info	[17]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Major		Inter Info	[18], [19], [17]
D0605		Esterified estrogens	NA	NA	Major		Inter Info	[17]
D0610		Estrone sulfate	C18H22O5S	3001028	Major		Inter Info	[18], [19], [17]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Major		Inter Info	[18], [19], [17]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[21]
D1011		Mestranol	C21H26O2	6291	Major		Inter Info	[18], [19], [17]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[22]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[23]
D1370		Quinestrol	C25H32O2	9046	Major		Inter Info	[17]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[26], [27], [28]
D0484		Dienestrol (topical)	C18H18O2	667476	Major		Inter Info	[18], [19], [17]
D0487		Diethylstilbestrol	C18H20O2	448537	Major		Inter Info	[17]
D0606		Estradiol	C18H24O2	5757	Major		Inter Info	[17]
D0607		Estradiol (topical)	C18H24O2	5757	Major		Inter Info	[18], [19], [17]
D0609		Estrone	C18H22O2	5870	Major		Inter Info	[17]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[18], [19], [17]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[26], [27], [28]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[42], [43], [44], [35], [37], [45], [46], [47], [48], [49], [50], [51], [52]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[56]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[42], [43], [44], [35], [37], [45], [46], [47], [48], [49], [50], [51], [52]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[57]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[58]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[42], [43], [44], [35], [37], [45], [46], [47], [48], [49], [50], [51], [52]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[37], [60]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[63]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[67], [68], [69], [70]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[35], [37], [71], [72], [73]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[37], [74]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[76], [77]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[35], [37], [78]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[67], [68], [69], [70]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[67], [68], [69], [70]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[37], [85]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[86]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[42], [43], [44], [35], [37], [45], [46], [47], [48], [49], [50], [51], [52]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[89], [90]
	Increased risk of hyperkalemia					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[35], [36], [37]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[35], [36], [37]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[75], [26], [35], [17], [37]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[75], [26], [35], [17], [37]

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91	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.

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