Drug General Information (ID: DDIAIN6LU1)
Drug Name			Amlodipine		Drug Info		Dantrolene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Muscle Relaxants
Structure

Mechanism of Amlodipine-Dantrolene Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Amlodipine				Dantrolene
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Amlodipine and Dantrolene

Recommended Action
Management		Due to the risk of hyperkalemia, European drug product labeling recommends that concomitant administration of amlodipine and dantrolene should generally be avoided in patients who are susceptible to malignant hyperthermia.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".