Details of Drug

Drug General Information (ID: D0069)
Drug Name	Amlodipine
Drug Type	Small molecule
Drug Synonymous	Amlocard; Amlodipino; Amlodipinum; Amlodis; Amlopres; Amlor; Coroval; Intervask; Lipinox; AMLODIPINE BASE; Amlodipine Free Base; Amlodipino [Spanish]; Amlodipinum [Latin]; Racemic Amlodipine; Amlodipine (INN); Amlodipine [INN:BAN]; Dailyvasc (TN); Istin (TN); Norvasc (TN); Perivasc (TN); UK-4834011; R,S)-Amlodipine; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl); 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-Ethyl-5-methyl (+/-)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-Ethyl-5-methyl (-)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat; 3-Ethyl-5-methyl (-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H25ClN2O5
InChI	1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChIKey	HTIQEAQVCYTUBX-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
External Link
	Pubchem ID	2162
	CAS Number	88150-42-9
	CHEBI ID	2668
	TTD ID	D08JIV
	VARIDT ID	DR00563

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM036 Additive cardiorespiratory depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM058 Increased risk of hyperkalemia BM075 Increased risk of photosensitivity reactions BM081 Increased risk of ventricular arrhythmias BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Amlodipine
Affected cellular transport
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[23], [25], [30]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[10], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
	CYP450 enzyme inhibition					Drug Num: 105
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[9], [15]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[16]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[17]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[35]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[36], [37]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[10], [88], [37]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[94]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [37], [17], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[10], [162]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[10], [163]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[168], [169]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[10], [171]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [37], [17], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[187]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[188]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[85], [10], [87]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[193], [37]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[194], [195]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[196]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[209]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[211]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[215], [216], [217]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[218], [219], [220], [221], [222], [108], [223], [215], [224], [216], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [217], [235], [236], [237], [238]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[9], [10]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[85], [9], [10], [248], [249]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[85], [10], [87]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[250]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[10], [251]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[252]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[10], [253]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[266]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[268], [269], [270], [271], [14], [272], [273], [274]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[278]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[9], [10], [279]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[281]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[289], [37]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[290]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[291]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[292]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[268], [269], [270], [271], [14], [272], [273], [274]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[298], [299]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[9], [10], [300], [301]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[85], [10], [87]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[302]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[10], [306]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[10], [313]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[315]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[268], [269], [270], [271], [14], [272], [273], [274]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[318]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[9], [319], [10], [320]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[9], [322]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[323]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[10], [325]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[326]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[327]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[9], [10]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[168], [169]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[9], [10]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[334]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[268], [269], [270], [271], [14], [272], [273], [274]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[335]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[338]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[268], [269], [270], [271], [14], [272], [273], [274]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[9], [10], [339], [86], [340], [341]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[218], [219], [220], [221], [222], [108], [223], [215], [224], [216], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [217], [235], [236], [237], [238]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[342]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[85], [9], [10], [86], [87]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[268], [269], [270], [271], [14], [272], [273], [274]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[343]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[344]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [37], [17], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[215], [216], [217]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[215], [216], [217]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[85], [9], [10], [86], [87]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[85], [9], [10]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[363]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[364]
D1721		Zileuton	C11H12N2O2S	60490	Minor		Inter Info	[370]
	CYP450 enzyme induction					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [3]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[4], [5], [6], [7], [8]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2], [3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2], [3]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1], [2], [3]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1], [2], [3]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [2], [3]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [2], [3]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1], [2], [3]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [2], [3]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [2], [3]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2], [3]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[82], [83], [84]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[170]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[177]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[10], [191]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[9], [207]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[208]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[210]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[214]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[239], [4], [240], [241], [242], [243]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[244]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[267]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[282]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[239], [4], [240], [241], [242], [243]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[82], [83], [84]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[307], [308], [309]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[10], [324]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[82], [83], [84]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[9], [10], [328]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[9], [10], [329], [328]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[85], [9], [10], [86]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[330]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[10], [331]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[82], [83], [84]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[10], [336], [337]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[82], [83], [84]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[9], [10], [346], [347]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[82], [83], [84]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[9], [10], [328]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[348], [349], [350], [351], [352], [353], [354]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[355], [356], [357], [358], [359]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[355], [356], [357], [358], [359]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[205], [206]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[9], [13], [14]
	Additive hypotensive effects					Drug Num: 121
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[19]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[34]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[68], [69], [70]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[71], [72], [73]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[71], [89], [90]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[91], [92], [93]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[159], [160], [161]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[164], [165], [166]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[91], [92], [93]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[91], [92], [93]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[164], [165], [166]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[164], [165], [166]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[164], [165], [166]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[164], [165], [166]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[9], [10], [176]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[9], [10], [176]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[197], [198], [199]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[9], [200], [201]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[164], [165], [166]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[164], [165], [166]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[164], [165], [166]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[164], [165], [166]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[164], [165], [166]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[9], [10], [176]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[10], [212], [213]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[72], [245]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[164], [165], [166]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[197], [198], [199]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[164], [165], [166]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[10], [212], [213]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[197], [198], [199]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[71], [89], [283]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[10], [287], [288]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[293], [294], [85], [10], [248], [295], [296]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[297]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[164], [165], [166]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[197], [198], [199]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[164], [165], [166]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[164], [165], [166]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[303], [304], [305]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[164], [165], [166]
D1183		Opium	NA	NA	Moderate		Inter Info	[164], [165], [166]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[164], [165], [166]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[164], [165], [166]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[314]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[164], [165], [166]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[321]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[10], [212], [213]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[197], [198], [199]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[164], [165], [166]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[164], [165], [166]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [72], [264], [265]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[159], [160], [161]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[164], [165], [166]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[164], [165], [166]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[164], [165], [166]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[197], [198], [199]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[164], [165], [166]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[164], [165], [166]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[164], [165], [166]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[159], [160], [161]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[10], [212], [213]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[74], [75], [76], [77], [68], [78], [69], [79], [70], [80], [81]
D0156		Benazepril	C24H28N2O5	5362124	Minor		Inter Info	[360], [361], [362]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Minor		Inter Info	[362]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Minor		Inter Info	[362]
D0254		Captopril	C9H15NO3S	44093	Minor		Inter Info	[360], [361], [362]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Minor		Inter Info	[362]
D0567		Enalapril	C20H28N2O5	5388962	Minor		Inter Info	[360], [361], [362]
D0695		Fosinopril	C30H46NO7P	55891	Minor		Inter Info	[360], [361], [362]
D0711		Garlic	NA	NA	Minor		Inter Info	[365], [366]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Minor		Inter Info	[362]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Minor		Inter Info	[362]
D0798		Indapamide	C16H16ClN3O3S	3702	Minor		Inter Info	[362]
D0938		Lisinopril	C21H31N3O5	5362119	Minor		Inter Info	[360], [361], [362]
D1048		Metolazone	C16H16ClN3O3S	4170	Minor		Inter Info	[362]
D1082		Moexipril	C27H34N2O7	91270	Minor		Inter Info	[360], [361], [362]
D1256		Perindopril	C19H32N2O5	107807	Minor		Inter Info	[360], [361], [362]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Minor		Inter Info	[362]
D1369		Quinapril	C25H30N2O5	54892	Minor		Inter Info	[360], [361], [362]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[367], [368]
D1618		Trandolapril	C24H34N2O5	5484727	Minor		Inter Info	[360], [361], [362]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Minor		Inter Info	[362]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Minor		Inter Info	[362]
D1379		Ramipril	C23H32N2O5	5362129	Minor		Inter Info	[360], [361], [362]
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[156], [157], [158]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[156], [157], [158]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[156], [157], [158]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[156], [157], [158]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[156], [157], [158]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[156], [157], [158]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[156], [157], [158]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[156], [157], [158]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[156], [157], [158]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[156], [157], [158]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[156], [157], [158]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[156], [157], [158]
	Increased risk of atrioventricular block					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[12]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[275]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[10], [345], [190]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[10], [369]
	Increased risk of bradycardia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[9], [10], [11]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[9], [18]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[172]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[10], [189], [190]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[202], [203], [204]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[246], [247]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[202], [203], [204]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[276], [277]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[280]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[310]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[85], [9], [10], [311], [312]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[202], [203], [204]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[202], [203], [204]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[276], [277]
	Increased risk of cardiac depression					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[41], [50], [58]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[41], [50], [58]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[41], [50], [58]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[41], [50], [58]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[41], [50], [58]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[41], [50], [58]
	Increased risk of hyperkalemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[9], [192], [10]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[316], [10], [317]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[9], [10], [333]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[65], [66], [67]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[10], [167]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[65], [66], [67]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[65], [66], [67]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[10], [167]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[173], [174], [175]
D0237		Calcium chloride	CaCl2H4O2	24844	Moderate		Inter Info	[173], [174], [175]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[173], [174], [175]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[173], [174], [175]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[173], [174], [175]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Moderate		Inter Info	[173], [174], [175]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[173], [174], [175]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[173], [174], [175]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[65], [66], [67]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[10], [167]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[10], [167]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[10], [167]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[65], [66], [67]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[65], [66], [67]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Moderate		Inter Info	[173], [174], [175]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[65], [66], [67]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[65], [66], [67]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[10], [167]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[65], [66], [67]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[10], [167]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[65], [66], [67]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[65], [66], [67]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[65], [66], [67]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[284], [285], [286]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[65], [66], [67]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[65], [66], [67]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[65], [66], [67]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[10], [167]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[65], [66], [67]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[65], [66], [67]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[65], [66], [67]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[65], [66], [67]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[65], [66], [67]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[10], [167]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[10], [167]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[65], [66], [67]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[65], [66], [67]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[65], [66], [67]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[10], [167]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[65], [66], [67]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[10], [167]
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[173], [174], [175]
D0240		Calcium glucoheptonate	C14H26CaO16	62859	Moderate		Inter Info	[173], [174], [175]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[65], [66], [67]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1905		Tetrofosmin	C18H40O4P2	4274	Moderate		Inter Info	[332]

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233	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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245	Product Information. Corlopam (fenoldopam). Neurex, Menlo Park, CA.
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248	Product Information. Adalat (nifedipine). Bayer, West Haven, CT.
249	Product Information. Nimotop (nimodipine). Bayer, West Haven, CT.
250	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
251	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
252	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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306	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
307	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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311	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
312	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
313	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
314	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
315	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
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318	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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320	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
321	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
322	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
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324	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
325	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
326	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
327	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
328	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
329	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
330	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
331	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
332	Product Information. Myoview (tetrofosmin). GE Healthcare, Princeton, NJ.
333	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
334	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
335	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
336	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
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338	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
339	Product Information. Neoral Soft Gelatin Capsules (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
340	Product Information. Sandimmune (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
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343	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
344	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
345	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
346	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
347	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
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356	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
357	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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363	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
364	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
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367	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
368	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
369	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
370	Product Information. Zylo Filmtab (zileuton). Abbott Pharmaceutical, Abbott Park, IL.

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