Drug General Information (ID: DDIMW3SN1K)
Drug Name			Ethanol		Drug Info		Dantrolene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Muscle Relaxants
Structure

Mechanism of Ethanol-Dantrolene Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Dantrolene
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Ethanol and Dantrolene

Recommended Action
Management		Patients receiving CNS-active agents should be advised to avoid or limit consumption of alcohol.

References
1	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
2	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
3	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.