Drug General Information (ID: DDIFP9MRO2)
Drug Name			Verapamil		Drug Info		Dantrolene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Muscle Relaxants
Structure

Mechanism of Verapamil-Dantrolene Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Verapamil				Dantrolene
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Verapamil and Dantrolene

Recommended Action
Management		The manufacturer recommends that concomitant administration should generally be avoided.

References
1	Rubin AS, Zablocki AD "Hyperkalemia, verapamil, and dantrolene." Anesthesiology 66 (1987): 246-9. [PMID: 3813090]
2	Canadian Pharmacists Association.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Product Information. Dantrium (dantrolene). Procter and Gamble Pharmaceutic, Cincinnati, OH.
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".