Details of Drug

Drug General Information (ID: D0193)
Drug Name	Bortezomib
Drug Type	Small molecule
Drug Synonymous	179324-69-7; Velcade; Bortezomib (PS-341); UNII-69G8BD63PP; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; MLN-341; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid; CHEMBL325041; 69G8BD63PP; Boronic acid,; DPBA; PROSCRIPT BORONIC ACID; LPD 341; LPD-341; VELCADE (TN); Velcade (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor); Peptide boronate Click to Show/Hide
Disease Class	2A83: Multiple myeloma; 2B33: Malignant haematopoietic neoplasm; 2A85: Mature B-cell lymphoma
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C19H25BN4O4
InChI	1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChIKey	GXJABQQUPOEUTA-RDJZCZTQSA-N
Canonical SMILES	B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
External Link
	Pubchem ID	387447
	CAS Number	179324-69-7
	CHEBI ID	52717
	TTD ID	D0SH3I
	INTEDE ID	DR0221
	VARIDT ID	DR01331

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Bortezomib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 51
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[57]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[9], [11], [12]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[16], [7], [61]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[9], [11], [12]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[9], [11], [12]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[9], [11], [12]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[9], [11], [12]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9], [11], [12]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[9], [11], [12]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[99]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[9], [11], [12]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[9], [11], [12]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [104]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[9], [11], [12]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[105], [106], [107], [108], [109], [110]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[7], [111]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[9], [11], [12]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[9], [11], [12]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[9], [11], [12]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[9], [11], [12]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[16], [7], [117], [118]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[9], [11], [12]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[9], [11], [12]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[120]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[9], [11], [12]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[9], [11], [12]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[9], [11], [12]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[141], [142]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[144]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[9], [11], [12]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[9], [11], [12]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[9], [11], [12]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[9], [11], [12]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[9], [11], [12]
D0263		Carisoprodol	C12H24N2O4	2576	Minor		Inter Info	[11]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[11]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[11]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[11]
D0603		Esomeprazole	C17H19N3O3S	9568614	Minor		Inter Info	[11]
D0665		Flibanserin	C20H21F3N4O	6918248	Minor		Inter Info	[11]
D1003		Mephenytoin	C12H14N2O2	4060	Minor		Inter Info	[11]
D1179		Omeprazole	C17H19N3O3S	4594	Minor		Inter Info	[11]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Minor		Inter Info	[11]
D1299		Pirfenidone	C12H11NO	40632	Minor		Inter Info	[11]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[11]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[11]
D1553		Terbinafine	C21H25N	1549008	Minor		Inter Info	[11]
D1677		Valproic acid	C8H16O2	3121	Minor		Inter Info	[163], [164], [11]
D1711		Warfarin	C19H16O4	54678486	Minor		Inter Info	[11]
	CYP450 enzyme induction					Drug Num: 54
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[9], [11], [12]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[9], [11], [12]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[7], [8], [9], [10], [11], [12]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[58]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[16], [102]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[16], [7], [116]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[7], [146]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[7], [8], [9], [11], [12]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[7], [8], [9], [11], [12]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[7], [8], [9], [11], [12]
D0194		Bosentan	C27H29N5O6S	104865	Minor		Inter Info	[7], [8], [9], [11], [12]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Minor		Inter Info	[7], [8], [9], [11], [12]
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[7], [8], [9], [11], [12]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[7], [8], [9], [11], [12]
D0300		Cenobamate	C10H10ClN5O2	11962412	Minor		Inter Info	[7], [8], [9], [11], [12]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Minor		Inter Info	[7], [8], [9], [11], [12]
D0432		Deferasirox	C21H15N3O4	214348	Minor		Inter Info	[7], [8], [9], [11], [12]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[7], [8], [9], [11], [12]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[7], [8], [9], [11], [12]
D0555		Elagolix	C32H30F5N3O5	11250647	Minor		Inter Info	[7], [8], [9], [11], [12]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Minor		Inter Info	[7], [8], [9], [11], [12]
D0628		Etravirine	C20H15BrN6O	193962	Minor		Inter Info	[7], [8], [9], [11], [12]
D0639		Felbamate	C11H14N2O4	3331	Minor		Inter Info	[7], [8], [9], [11], [12]
D0741		Griseofulvin	C17H17ClO6	441140	Minor		Inter Info	[7], [8], [9], [11], [12]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[7], [8], [9], [11], [12]
D0901		Lemborexant	C22H20F2N4O2	56944144	Minor		Inter Info	[7], [8], [12]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Minor		Inter Info	[7], [8], [9], [11], [12]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[7], [8], [12]
D1050		Metreleptin	NA	NA	Minor		Inter Info	[7], [8], [9], [11], [12]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[7], [8], [9], [11], [12]
D1099		Nafcillin	C21H22N2O5S	8982	Minor		Inter Info	[7], [8], [9], [11], [12]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[7], [8], [9], [11], [12]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Minor		Inter Info	[7], [8], [9], [11], [12]
D1190		Osimertinib	C28H33N7O2	71496458	Minor		Inter Info	[7], [8], [9], [11], [12]
D1198		Oxcarbazepine	C15H12N2O2	34312	Minor		Inter Info	[7], [8], [9], [11], [12]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[7], [8], [9], [11], [12]
D1274		Phenylbutazone	C19H20N2O2	4781	Minor		Inter Info	[7], [8], [9], [11], [12]
D1433		Rufinamide	C10H8F2N4O	129228	Minor		Inter Info	[7], [8], [9], [11], [12]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[7], [8], [9], [11], [12]
D1493		Somapacitan	C54H95N13O20S2	129894493	Minor		Inter Info	[7], [8], [12]
D1495		Somatrem	C43H72N14O14	5487805	Minor		Inter Info	[7], [8], [9], [11], [12]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Minor		Inter Info	[7], [8], [9], [11], [12]
D1538		Tazemetostat	C34H44N4O4	66558664	Minor		Inter Info	[7], [8], [9], [11], [12]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[7], [8], [9], [11], [12]
D1494		Somatotropin	NA	NA	Minor		Inter Info	[7], [8], [12]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[16], [7], [17]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [18]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[23]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [27]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[16], [30]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[34]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[35]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[36]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[31], [37], [38]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[39]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[40], [41], [42]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[16], [7]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[100]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[101]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[101]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[101]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[121]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[122]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [123]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[124]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[136]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [140]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[143]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[16], [7], [145]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[149]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[151]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[16], [7], [155]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[160]
	Additive myelosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [19], [20]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[16], [21], [22]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[29]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[16], [7], [152], [153]
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[24]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[25]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[28]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[46], [47], [48], [16], [7], [49], [50], [51], [52], [53], [54], [55], [56]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[46], [47], [48], [16], [7], [49], [50], [51], [52], [53], [54], [55], [56]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[64]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[65], [66]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[46], [47], [48], [16], [7], [49], [50], [51], [52], [53], [54], [55], [56]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[76]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[16], [7], [103]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[112]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[119]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[125], [126], [127], [128]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[16], [7], [137], [138], [139]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[147], [148]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[7], [150]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[125], [126], [127], [128]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[125], [126], [127], [128]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[46], [47], [48], [16], [7], [49], [50], [51], [52], [53], [54], [55], [56]
	Increased risk of peripheral neuropathy					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[59], [60], [11]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[59], [60], [11]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[59], [60], [11]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[59], [60], [11]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[59], [60], [11]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[59], [60], [11]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[59], [60], [11]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[59], [60], [11]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[59], [60], [11]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[59], [60], [11]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[59], [60], [11]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[59], [60], [11]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[59], [60], [11]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[59], [60], [11]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[59], [60], [11]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[59], [60], [11]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[59], [60], [11]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[59], [60], [11]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[59], [60], [11]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[59], [60], [11]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[59], [60], [11]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[59], [60], [11]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[59], [60], [11]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[59], [60], [11]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[59], [60], [11]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[59], [60], [11]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[59], [60], [11]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[59], [60], [11]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[59], [60], [11]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[59], [60], [11]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[59], [60], [11]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[59], [60], [11]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[59], [60], [11]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[59], [60], [11]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[59], [60], [11]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[59], [60], [11]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[59], [60], [11]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[59], [60], [11]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[59], [60], [11]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[59], [60], [11]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[59], [60], [11]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[59], [60], [11]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[59], [60], [11]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[59], [60], [11]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[59], [60], [11]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[59], [60], [11]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[59], [60], [11]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[59], [60], [11]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[59], [60], [11]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[59], [60], [11]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[59], [60], [11]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[59], [60], [11]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[59], [60], [11]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[59], [60], [11]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[59], [60], [11]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[59], [60], [11]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[59], [60], [11]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[59], [60], [11]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[59], [154]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[59], [60], [11]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[59], [60], [11]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[59], [60], [11]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[59], [60], [11]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[59], [60], [11]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[59], [60], [11]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[59], [60], [11]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[13], [14], [15]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[13], [14], [15]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[13], [14], [15]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[31], [16], [32]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[33]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[13], [14], [15]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[13], [14], [15]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [62], [63]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[31], [62], [63]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[129], [31], [16], [130], [131], [132], [62], [133], [134], [135], [63]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [62], [63]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[31], [62], [63]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[31], [62], [63]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[159]
	Antagonize the effect of probiotics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[113], [114], [115]
	Diminish the response to diagnostic skin test antigens					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[96], [97], [98]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[96], [97], [98]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[96], [97], [98]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0111		Ascorbic acid	C6H8O6	54670067	Moderate		Inter Info	[43], [44], [45]
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[156], [157], [158]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[161], [162]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[156], [157], [158]

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97	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
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