Drug General Information (ID: DDIJ7ELHDP)
Drug Name			Bortezomib		Drug Info		Secnidazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Amebicides/Antibiotics
Structure

Mechanism of Bortezomib-Secnidazole Interaction (Severity Level: Moderate)
Increased risk of peripheral neuropathy Click to Show/Hide Mechanism Graph
Drug Name		Bortezomib				Secnidazole
Mechanism		Peripheral neuropathy				Peripheral neuropathy
Key Mechanism Factor 1
		Factor Name		Peripheral neuropathy
		Factor Description		Peripheral neuropathy is a disorder of the peripheral nerves that can cause sensory and motor symptoms, and even paralysis in severe cases. Signs and symptoms of peripheral neuropathy may include: gradual numbness, tingling or prickling in the feet or hands that can spread up the legs and arms; sharp, stinging, pricking or burning sensations; extreme sensitivity to touch; pain during activities that should not cause pain; lack of coordination and falls; muscle weakness; and paralysis if the motor nerves are affected.
Mechanism Description		Increased risk of peripheral neuropathy by the combination of Bortezomib and Secnidazole

Recommended Action
Management		Caution is advised if bortezomib is used with other neurotoxic agents. Patients should be closely monitored for symptoms of neuropathy such as visual disturbances or burning, tingling, pain, numbness, and/or weakness in the extremities. Patients experiencing new or worsening peripheral neuropathy may require an adjustment in the dosage and schedule of bortezomib in accordance with the product labeling.

References
1	Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
2	Cavaletti G, Jakubowiak AJ "Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies." Leuk Lymphoma 51 (2010): 1178-87. [PMID: 20497001]
3	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.