Details of Drug

Drug General Information (ID: D1452)
Drug Name	Secnidazole
Drug Type	Small molecule
Drug Synonymous	3366-95-8; Secnidazol; Secnidazolum; Flagentyl; Secnidazolum [INN-Latin]; Solosec; RP 14539; Secnidazol [INN-Spanish]; PM 185184;Secnidazole (Flagentyl); SYM-1219; EINECS 222-134-0; seknidazol; MLS000559043; PM-185184; NCGC00095158-01; SMR000149359; RP-14539 Click to Show/Hide
Disease Class	MF3A: Vaginal discharge; 1A36: Amoebiasis
Therapeutic Class	Amebicides/Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C7H11N3O3
InChI	1S/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3
InChIKey	KPQZUUQMTUIKBP-UHFFFAOYSA-N
Canonical SMILES	CC1=NC=C(N1CC(C)O)[N+](=O)[O-]
External Link
	Pubchem ID	71815
	CAS Number	3366-95-8
	CHEBI ID	94433
	TTD ID	D0V5IW
	INTEDE ID	DR2431

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Secnidazole
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[17], [18]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[17], [18]
Pharmacodynamic additive effects
	Increased risk of peripheral neuropathy					Drug Num: 77
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[5], [6], [7]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[5], [6], [7]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[5], [6], [7]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[5], [6], [7]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[5], [6], [7]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[8], [9], [10]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[5], [11], [12]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[5], [6], [7]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[5], [6], [7]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[5], [6], [7]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[5], [6], [7]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[5], [6], [7]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[5], [6], [7]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[5], [6], [7]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[5], [6], [7]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[5], [6], [7]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[5], [6], [7]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[5], [6], [7]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[5], [6], [7]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[5], [6], [7]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[5], [6], [7]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[5], [6], [7]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[5], [6], [7]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[5], [6], [7]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[5], [6], [7]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[5], [6], [7]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[5], [6], [7]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[5], [6], [7]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[5], [6], [7]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[5], [6], [7]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[5], [6], [7]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[5], [6], [7]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[5], [6], [7]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[5], [6], [7]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[5], [6], [7]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[5], [6], [7]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[5], [6], [7]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[5], [6], [7]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[5], [6], [7]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[5], [6], [7]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[5], [6], [7]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[5], [6], [7]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[5], [6], [7]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[5], [6], [7]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[5], [6], [7]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[5], [6], [7]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[5], [6], [7]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[5], [6], [7]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[5], [6], [7]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[5], [6], [7]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[5], [6], [7]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[5], [6], [7]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[8], [22], [1], [23]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[5], [6], [7]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[5], [6], [7]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[5], [6], [7]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[5], [6], [7]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[5], [6], [7]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[5], [6], [7]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[5], [6], [7]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[1], [2], [3]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[4]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[13]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[14], [15], [16]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[19], [20], [21]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	UK government "Typhoid.".
3	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
4	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
5	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
6	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
7	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
8	Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
9	Cavaletti G, Jakubowiak AJ "Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies." Leuk Lymphoma 51 (2010): 1178-87. [PMID: 20497001]
10	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
11	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
12	Product Information. Danyelza (naxitamab). Y-mAbs Therapeutics, New York, NY.
13	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
14	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
15	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
16	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
17	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
18	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
19	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
20	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
21	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
22	Cerner Multum, Inc. "Australian Product Information.".
23	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.

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