Drug General Information (ID: DDIZKNOQ78)
Drug Name			Indium In-111 oxyquinoline		Drug Info		Secnidazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diagnostic Radiopharmaceuticals				Amebicides/Antibiotics
Structure

Mechanism of Indium In-111 oxyquinoline-Secnidazole Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Indium In-111 oxyquinoline				Secnidazole
Mechanism		Indium In-111 oxyquinoline				Cause false-negative results with Indium In-111-labeled leukocyte studies
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Indium In-111 oxyquinoline when combined with Secnidazole

Recommended Action
Management		Clinicians should be aware of possible diagnostic interference in patients who are on long-term antibiotic treatment, corticosteroids, interleukin-2, parenteral nutrition, or high doses or supratherapeutic concentrations of lidocaine or procainamide.

References
1	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.