Details of Drug

Drug General Information (ID: D0130)
Drug Name	Avatrombopag
Drug Type	Small molecule
Drug Synonymous	AVATROMBOPAG; 570406-98-3; AKR-501; UNII-3H8GSZ4SQL; 3H8GSZ4SQL; AKR 501; Avatrombopag [USAN:INN]; Doptelet; AS 1670542; Avatrombopag (USAN/INN); GTPL9953; DTXSID30205667; ZINC72190218; AKOS027323962; CS-3397; HY-13463; FT-0728753; D10306; AS1670542 Click to Show/Hide
Disease Class	3B64: Thrombocytopenia
Therapeutic Class	Platelet-Stimulating Agents
Structure
Structure	3D Structure		2D Structure
Formula	C29H34Cl2N6O3S2
InChI	1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)
InChIKey	OFZJKCQENFPZBH-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
External Link
	Pubchem ID	9852519
	CAS Number	570406-98-3
	TTD ID	D0W1DI

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM047 Additive thrombogenic effects BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Avatrombopag
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[3], [5], [9]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1], [2]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[5], [7], [8]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[5], [7], [8]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[5]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[5]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[5]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[5], [7], [8]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[3], [5], [12]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[5]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[5]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[5]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[5]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[5]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[5]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[13]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[5]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[5]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[16], [3], [17]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[5]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[5]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[5]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[5], [7], [8]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[5]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[18]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[5]
	CYP450 enzyme induction					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1], [2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [6], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[5]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[10], [11]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[5], [14], [15]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[5]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[5]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[5]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[5]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[3], [4], [5]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[5], [2]
D0825		Interferon alfa-n3	NA	NA	Moderate		Inter Info	[5], [2]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[5], [2]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[5], [2]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[5], [2]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[5], [2]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[5], [2]

References
1	Nomo, Zamora, Schuck, et al. "Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting." PubMed 84 (2018): 1. [PMID: 29341245]
2	Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals, Durham, NC.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
7	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
8	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
9	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
10	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
11	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
12	Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
13	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
14	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
15	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
16	Canadian Pharmacists Association.
17	Product Information. Orfadin (nitisinone). Orphan Pharmaceuticals USA, Inc, Nashville, TN.
18	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.

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