Drug General Information (ID: DDI7HL60RE)
Drug Name			Peginterferon beta-1a		Drug Info		Avatrombopag		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Interferons				Platelet-Stimulating Agents

Mechanism of Peginterferon beta-1a-Avatrombopag Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Peginterferon beta-1a				Avatrombopag
Mechanism		Reduce therapeutic efficacy of avatrombopag				Avatrombopag
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Peginterferon beta-1a when combined with Avatrombopag

Recommended Action
Management		Patients should be monitored for decreased response to avatrombopag during concomitant treatment with interferon preparations.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals, Durham, NC.