Drug General Information (ID: DDIOI15EW2)
Drug Name			Interferon beta-1b		Drug Info		Avatrombopag		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Immunomodulatory Agents				Platelet-Stimulating Agents

Mechanism of Interferon beta-1b-Avatrombopag Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Interferon beta-1b				Avatrombopag
Mechanism		Reduce therapeutic efficacy of avatrombopag				Avatrombopag
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Interferon beta-1b when combined with Avatrombopag

Recommended Action
Management		Patients should be monitored for decreased response to avatrombopag during concomitant treatment with interferon preparations.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals, Durham, NC.