Details of Drug

Drug General Information (ID: D0055)
Drug Name	Amifostine
Drug Type	Small molecule
Drug Synonymous	Ethiofos; Ethyol; Gammaphos; WR-1064; WR-2721; WR-2721C; YM-08310 Click to Show/Hide
Disease Class	CA00: Nasopharyngitis
Therapeutic Class	Cytoprotective Agent
Structure
Structure	3D Structure		2D Structure
Formula	C5H15N2O3PS
InChI	1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
InChIKey	JKOQGQFVAUAYPM-UHFFFAOYSA-N
Canonical SMILES	C(CN)CNCCSP(=O)(O)O
External Link
	Pubchem ID	2141
	CAS Number	20537-88-6
	CHEBI ID	2636
	TTD ID	D06CIE
	INTEDE ID	DR0085

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM042 Additive hypotensive effects BM063 Increased risk of hypocalcemia
Relation Graph

Full list of drugs interacting with Amifostine
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 104
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[2], [3], [4]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[2], [3], [4]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[2], [3], [4]
D0082		Amrinone	C10H9N3O	3698	Moderate		Inter Info	[2], [3], [4]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[2], [3], [4]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[2], [3], [4]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[2], [3], [4]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[2], [3], [4]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[2], [3], [4]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[2], [3], [4]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[2], [3], [4]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[2], [3], [4]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[2], [3], [4]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[2], [3], [4]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[2], [3], [4]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[2], [3], [4]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[2], [3], [4]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[2], [3], [4]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[2], [3], [4]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[2], [3], [4]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[2], [3], [4]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[2], [3], [4]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[2], [3], [4]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[2], [3], [4]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[2], [3], [4]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[2], [3], [4]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[2], [3], [4]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[2], [3], [4]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[2], [3], [4]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[2], [3], [4]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[2], [3], [4]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[2], [3], [4]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[2], [3], [4]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[2], [3], [4]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[2], [3], [4]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[2], [3], [4]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[2], [3], [4]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[2], [3], [4]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[2], [3], [4]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2], [3], [4]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[2], [3], [4]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[2], [3], [4]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[2], [3], [4]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[2], [3], [4]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[2], [3], [4]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[2], [3], [4]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[2], [3], [4]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[2], [3], [4]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[2], [3], [4]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[2], [3], [4]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[2], [3], [4]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[2], [3], [4]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[2], [3], [4]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[2], [3], [4]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[2], [3], [4]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[2], [3], [4]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[2], [3], [4]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[2], [3], [4]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[2], [3], [4]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[2], [3], [4]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[2], [3], [4]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[2], [3], [4]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[2], [3], [4]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[2], [3], [4]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[2], [3], [4]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[2], [3], [4]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[2], [3], [4]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[2], [3], [4]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[2], [3], [4]
D1067		Milrinone	C12H9N3O	4197	Moderate		Inter Info	[2], [3], [4]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[2], [3], [4]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[2], [3], [4]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[2], [3], [4]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[2], [3], [4]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[2], [3], [4]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[2], [3], [4]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[2], [3], [4]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[2], [3], [4]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[2], [3], [4]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[2], [3], [4]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[2], [3], [4]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[2], [3], [4]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[2], [3], [4]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[2], [3], [4]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[2], [3], [4]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2], [3], [4]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[2], [3], [4]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[2], [3], [4]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[2], [3], [4]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[2], [3], [4]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[2], [3], [4]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[2], [3], [4]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[2], [3], [4]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[2], [3], [4]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[2], [3], [4]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[2], [3], [4]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[2], [3], [4]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[2], [3], [4]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[2], [3], [4]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[2], [3], [4]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[2], [3], [4]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[2], [3], [4]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[2], [3], [4]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[2], [3], [4]
	Increased risk of hypocalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[5], [6], [7]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
3	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
4	Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
5	Foscarnet: a review. Drugs 41 (1991): 106-29. [PMID: 1706982]
6	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.
7	Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6. [PMID: 2898602]

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