Details of Drug

Details of Drug

 Drug General Information (ID: D0022)
  Drug Name
Acyclovir
  Drug Type Small molecule
  Drug Synonymous
acyclovir; Acycloguanosine; 59277-89-3; Zovirax; Vipral; Virorax; Wellcome-248U; 9-[(2-Hydroxyethoxy)methyl]guanine; Aciclovirum; Zovir; Aciclovirum [Latin]; Sitavig; Aciclovier; Zyclir; 9-HYROXYETHOXYMETHYLGUANINE; Aciclovirum [INN-Latin]; 2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one; W-248-U; 9-(2-Hydroxyethoxy)methylguanine; Acyclovir-side chain-2-3H; ACYCLOVIR SODIUM; 9-((2-Hydroxyethoxy)methyl)guanine; Acicloftal; Cargosil; BW-248U; UNII-X4HES1O11F; DRG-0008; NSC 645011; CHEBI:2453; CCRIS 1953; Iontophoretic acyclovir
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  Disease Class 1A24-1D9Z: Virus infection; 1F00: Herpes simplex infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C8H11N5O3
  InChI 1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
  InChIKey MKUXAQIIEYXACX-UHFFFAOYSA-N
  Canonical SMILES C1=NC2=C(N1COCCO)N=C(NC2=O)N
  External Link
Pubchem ID 135398513
CAS Number 59277-89-3
CHEBI ID 2453
TTD ID D0B5MP
VARIDT ID DR00325

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM017  CYP450 enzyme inhibition
BM027  Decreased renal excretion due to nephrotoxicity
BM028  Competitive inhibition of renal tubular secretion
BM072  Increased risk of nephrotoxicity
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Acyclovir
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23]
D1378
 
Ramelteon
 
C16H21NO2
 
208902 
Moderate    Inter Info   
[29]
      Affected excretion pathways
   Decreased renal excretion due to nephrotoxicity Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[28], [4], [30], [31], [32]
   Competitive inhibition of renal tubular secretion Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[37]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[38]
D1656
 
Trospium
 
C25H30NO3+
 
5284632 
Moderate    Inter Info   
[4], [39], [40]
D0998
 
Memantine
 
C12H21N
 
4054 
Minor    Inter Info   
[41], [42], [43]
      Pharmacodynamic additive effects
   Increased risk of nephrotoxicity Drug Num:  25
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Major    Inter Info   
[1], [2], [3]
D0805
 
Inotersen
 
C230H318N69O121P19S19
 
121492004 
Major    Inter Info   
[4], [5]
D0831
 
Iodipamide
 
C20H14I6N2O6
 
3739 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0832
 
Iodixanol
 
C35H44I6N6O15
 
3724 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0836
 
Iopromide
 
C18H24I3N3O8
 
3736 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0837
 
Iothalamic acid
 
C11H9I3N2O4
 
3737 
Major    Inter Info   
[8], [9], [10]
D0838
 
Ioversol
 
C18H24I3N3O9
 
3741 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0839
 
Ioxilan
 
C18H24I3N3O8
 
3743 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Major    Inter Info   
[1], [2], [3]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Major    Inter Info   
[1], [2], [3]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Major    Inter Info   
[1], [2], [3]
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Major    Inter Info   
[15]
D0472
 
Diatrizoate
 
C11H9I3N2O4
 
2140 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12]
D0145
 
Balsalazide
 
C17H15N3O6
 
54585 
Moderate    Inter Info   
[24], [25], [26], [27]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Moderate    Inter Info   
[28], [4]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Moderate    Inter Info   
[28], [4]
D1173
 
Olsalazine
 
C14H10N2O6
 
22419 
Moderate    Inter Info   
[24], [25], [26], [27]
D1304
 
Plazomicin
 
C25H48N6O10
 
42613186 
Moderate    Inter Info   
[28], [4]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Moderate    Inter Info   
[24], [25], [26], [27]
D0292
 
Ceftazidime
 
C22H22N6O7S2
 
5481173 
Moderate    Inter Info   
[28], [4]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[36]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[28], [4]
D1009
 
Mesalazine
 
C7H7NO3
 
4075 
Moderate    Inter Info   
[25], [26], [27]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[13], [14]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Moderate    Inter Info   
[33]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Moderate    Inter Info   
[4], [34], [35]
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