Drug General Information (ID: DDIMN5HEL1)
Drug Name			Acyclovir		Drug Info		Varicella Zoster Vaccine (Recombinant)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antiviral Agents				Vaccine

Mechanism of Acyclovir-Varicella Zoster Vaccine (Recombinant) Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Acyclovir				Varicella Zoster Vaccine (Recombinant)
Mechanism		Impairs immunomodulatory viral infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Varicella Zoster Vaccine (Recombinant) when combined with Acyclovir

Recommended Action
Management		Acyclovir, famciclovir, and valacyclovir should not be used for at least 24 hours before administration of live, attenuated varicella virus vaccine or zoster vaccine. In addition, these antiviral agents should generally be avoided for 14 days after vaccination.

References
1	US Centers for Disease Control and Prevention (CDC) "Recommended immunization schedule for adults aged 19 years or older, United States, 2017.".
2	Product Information. Zovirax (acyclovir). Mylan Pharmaceuticals Inc, Morgantown, WV.