Drug General Information (ID: DDIKZIC32A)
Drug Name			Acyclovir		Drug Info		Talimogene laherparepvec		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antiviral Agents				Anticancer Agents

Mechanism of Acyclovir-Talimogene laherparepvec Interaction (Severity Level: Moderate)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Acyclovir				Talimogene laherparepvec
Mechanism		Impairs immunomodulatory viral infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Talimogene laherparepvec when combined with Acyclovir

Recommended Action
Management		Because talimogene laherparepvec is sensitive to antiviral agents such as acyclovir, the risks and benefits of talimogene laherparepvec should be considered before administering antiviral agents to manage herpetic infection.

References
1	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.