Drug General Information (ID: DDIK7812IH)
Drug Name			Cladribine		Drug Info		Acyclovir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antiviral Agents
Structure

Mechanism of Cladribine-Acyclovir Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Cladribine				Acyclovir
Mechanism		Prodrug activated by intracellular phosphorylation				Intracellular phosphorylation inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Cladribine when combined with Acyclovir

Recommended Action
Management		Concomitant use of cladribine with medications that undergo intracellular phosphorylation should be avoided if possible.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.